৳ 1,000/unit
Pack: ৳ 1,000
৳ 1,000/unit
Pack: ৳ 1,000
At a glance
Iohexol is a contrast agent used to enhance the visibility of internal body structures before an X-ray test.
Indications
- Angiocardiography
- Aortography
- Intravenous digital subtraction angiography
- Peripheral arteriography
- Excretory urography
- CT scanning
Pharmacology
Iohexol is a nonionic, water-soluble radiographic contrast medium. It blocks X-rays as they pass through the body, thereby allowing body structures not containing iodine to be visualized. The degree of opacity produced by Iohexol is directly proportional to the total amount of the iodinated contrast agent in the path of the X-rays. Visualization of body structures is dependent upon the distribution and elimination of Iohexol.
Dosage
Adult Dose (Intravascular):
- Ventriculography: 40 mL (range 30-60 mL); may repeat as needed, not to exceed 250 mL
- Selective Coronary Arteriography: 5 mL (range 3-14 mL per injection)
- Aortic Root and Arch Study: 50 mL (range 20-75 mL)
- Pulmonary Angiography: 1 mL/kg
- CT Scanning (Head): 70-150 mL (Iohexol 300); 80 mL (Iohexol 350)
- CT Scanning (Body): 50-200 mL (Iohexol 300); 60-100 mL (Iohexol 350)
- Excretory Urography: 200-350 mgI/kg body weight
Child Dose (Intravascular):
- Angiocardiography: 1.25-1.75 mL/kg; not to exceed 5-6 mL/kg or 250-291 mL
- CT Scanning: 1-2 mL/kg
Side effects
Common Side Effects:
- Nausea (2%)
- Vomiting (0.7%)
- Diarrhea
Cardiovascular: Arrhythmias (PVCs, PACs), angina/chest pain, hypotension, cardiac failure, asystole, bradycardia, tachycardia
Nervous System: Vertigo, pain, vision abnormalities, headache, taste perversion, convulsion, paresthesia, somnolence, syncope
Skin: Urticaria, purpura, pruritus
Use in pregnancy
Use in Pregnancy: Category B; no adequate studies in pregnant women; use only if potential benefit justifies potential risk to fetus.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- It is not known whether Iohexol alters ability to drive; do not drive if you experience symptoms affecting concentration and reaction
- Emergency facilities should be available for 30-60 minutes after parenteral administration
- Preparatory dehydration is dangerous and may contribute to acute renal failure; patients should be well hydrated
- Caution in patients with history of allergies or hypersensitivity
- Caution in patients with congestive heart failure
- Avoid angiography in patients with homocystinuria
Overdose effects
Overdose: Adverse effects are life-threatening and affect mainly pulmonary and cardiovascular systems; symptoms include cyanosis, bradycardia, acidosis, pulmonary hemorrhage, convulsions, coma, cardiac arrest; treatment is supportive and symptomatic.
Storage conditions
Store at room temperature below 30°C; protect from light and secondary X-rays; do not freeze.