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At a glance

Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) used for the treatment of premature ejaculation in adult men aged 18 to 64 years. It increases the time to ejaculate and improves control over ejaculation.

Indications
  • Premature ejaculation (men 18 to 64 years of age)
Pharmacology

The mechanism of action of Dapoxetine in premature ejaculation is presumed to be linked to the inhibition of neuronal reuptake of serotonin and the subsequent potentiation of the neurotransmitter's action at pre-and post synaptic receptors. Dapoxetine is rapidly absorbed with maximum plasma concentrations occurring approximately 1-2 hours after tablet intake. It has a rapid elimination with a terminal half life of approximately 19 hours.

Dosage

Adult (18-64 years): Initial dose 30 mg, taken approximately 1-3 hours before sexual activity. May be increased to 60 mg if needed. Maximum once every 24 hours. Review treatment after 4 weeks (6 doses) and at least every 6 months thereafter.

Side effects

Common: Headache, dizziness, drowsiness, nausea, vomiting, diarrhea, insomnia, dry mouth, fatigue, increased sweating, restlessness, erectile dysfunction (<4%), loss of libido (<1%).

Use in pregnancy

Dapoxetine is not indicated for use in women. Information regarding use during pregnancy is not available. Please consult your doctor.

Pregnancy Category: N/A — always consult a doctor before taking during pregnancy.

Precautions & warnings

May affect driving ability (drowsiness, dizziness, difficulty concentrating, blurred vision). Avoid alcohol. Caution in patients with history of seizures, depression, psychiatric disorders. Rise slowly due to orthostatic hypotension. Caution with PDE5 inhibitors and alpha-adrenergic receptor antagonists. Caution in patients with bleeding or coagulation disorders.

Overdose effects

No case of overdose has been reported. Up to 240 mg daily showed no unexpected adverse events. Symptoms of SSRI overdose may include somnolence, GI disturbances, tachycardia, tremor, agitation, and dizziness.

Storage conditions

Store below 30°C, protected from light and moisture. Keep out of reach of children.

Dapoxetine — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.