Eltrom 25
Rx- Generic:
- Eltrombopag Olamine
- Company:
- Jenphar Bangladesh Ltd.
- Dosage form:
- Tablet
- Pack size:
- Box (7 Tablet)
৳ 600/unit
Pack: ৳ 4,200
At a glance
Eltrombopag Olamine — brands, prices, indication, dosage and side effects available in Bangladesh.
Description
Eltrombopag Olamine is used to treat low platelet count due to chronic immune (idiopathic) thrombocytopenic purpura (ITP) or chronic hepatitis C virus (HCV) infection. It is also used to treat severe aplastic anemia. Eltrombopag Olamine is a thrombopoietin agonist. It works by stimulating the formation of new platelets in the blood. The function of platelets is to help reduce bleeding. It should be taken in a dose and duration as advised by the doctor. You may take it on an empty stomach. This medicine is to be swallowed as a whole. Do not chew, crush or break it. Inform your doctor if you have any known allergy from this medication. The common side effects include nausea, vomiting or diarrhea. Inform your doctor if you are pregnant or breastfeeding or suffering from liver diseases as a dose adjustment may be required. It is safe to use in patients suffering from kidney diseases. It is not advised to drive after taking this medicine as you may feel dizzy making you less alert. Eltrombopag Olamine is a thrombopoietin agonist. It works by stimulating the formation of new platelets in the blood. Platelets help to reduce or prevent bleeding.
Indications
• Low platelet count due to ITP or HCV infection
Mechanism of action
Small-molecule thrombopoietin (TPO)-receptor agonist that interacts with human TPO receptor transmembrane domain of human TPO-receptor & initiates signaling cascades that induce proliferation & differentiation of megakaryocytes from bone marrow progenitor cells.
Dosage
Adult Dose: Adult Chronic ITP: Initial dose 50 mg once daily. Adjust to maintain platelet count greater than or equal to 50×109 /L Chronic hepatitis C associated thrombocytopenia: Initial recommended dose is 50 mg once daily and do not exceed a daily dose of 100 mg. Severe aplastic anemia: Initial recommended dose is 50 mg once daily, adjust to maintain platelet count greater or equal 50×109 /L. Do not exceed 150 mg per day Max: 75 mg daily. After adjustment, platelet counts should be monitored at least weekly for 2-3 weeks. Wait for at least 2 weeks to see the effect of any dose adjustment on the patient’s platelet response prior to considering another dose adjustment. Hepatic Impairment: Should not be used in ITP patients with liver cirrhosis (hepatic impairment unless the expected benefit outweighs the identified risk of portal venous thrombosis. Child Dose: Child 6 years or older Chronic ITP: Initial dose 50 mg once daily. Child 1 to 5 year The initial dose is 25 mg once daily. Adjust to maintain platelet count greater than or equal to 50×109 /L Renal Dose: Renal Impairment: No dose adjustment is necessary in ITP patients with renal impairment.
Administration
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Eltrombopag Olamine is to be taken empty stomach.
Missed dose
If you miss a dose of Eltrombopag Olamine, skip it and continue with your normal schedule. Do not double the dose.
Side effects
Common: • Nausea • Diarrhea • Upper respiratory tract infection • Vomiting • Increased liver enzymes • Muscle pain • Urinary tract infection
Precautions & warnings
[UNSAFE] Eltrombopag Olamine may cause side effects which could affect your ability to drive. Eltrombopag Olamine can make you dizzy and have other side effects that make you less alert. This may affect your driving ability. Take Eltrombopag Olamine on an empty stomach, either 1 hour before or 2 hours after meals. Take Eltrombopag Olamine at least 2 hours before or 4 hours after eating dairy products and calcium-fortified juices.
Contraindications
Eltrombopag is contraindicated in patients with severe hepatic impairment and who are hypersensitive to any of its excipients.
Drug interactions
Increased plasma Cmax & AUC of HMG-CoA reductase inhibitors. Caution w/ methotrexate, topotecan. Increased conc w/ fluvoxamine; decreased conc w/ rifampicin & lopinavir/ritonavir. Reduced absorption by antacids, dairy products & other products containing polyvalent cations (eg Fe, Ca, Mg, Al, Se, Zn). Reduced plasma AUC & Cmax w/ high-calorie & -fat meal. Monitor platelet counts when used in combination w/ lopinavir/ritonavir & other drugs for treatment of idiopathic thrombocytopenic purpura (ITP).
Food interactions
[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Eltrombopag Olamine. Please consult your doctor.
Use in pregnancy
[CONSULT YOUR DOCTOR] Eltrombopag Olamine may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Use in lactation
[CONSULT YOUR DOCTOR] Eltrombopag Olamine is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Renal / hepatic impairment
[SAFE IF PRESCRIBED] Eltrombopag Olamine is safe to use in patients with kidney disease. No dose adjustment of Eltrombopag Olamine is recommended. However, inform your doctor if you have a kidney disease. Regular monitoring of kidney function tests may is advisable while you are taking this medicine. [CAUTION] Eltrombopag Olamine should be used with caution in patients with liver disease. Dose adjustment of Eltrombopag Olamine may be needed. Please consult your doctor.
Common questions
I have Low Platlets. How to get revolade 25 mg tablet with my coupon code. Hi PATIENT you consulted any doctor Low platelet count ( ITP) since 2013 about 20000 only Are you taking any medicine for this. ITP CASE What the best medicine to get out of it Sir I am an ITP case Suffering from low platelet count Please share your reports. Mh mother have blood cancer .recently she got her first induction chemotherapy.in CBC test Immature myeloid cells 18 percent what are indicate.is it serious .is it shown presence of cancer in blood old tell me Dear Mam Greetings from 1mg, The reports shows low hemoglobin and platelet count which can be due to chemotherapy. Severe Aplastic Anemia.On 100mg cyclosporine and 25mg eltrombopag.ATG done from may5th to may 8th.At present counts have raised to Hb 8.4, platelets 120000, and wbc 5000.her last Appointment with doctor was on sep 26th and then platelets were 60000.Hence the revolade dosage was reduced to 25mg daily from 50mg daily and next appointment is on nov 26th.now just for our satisfaction we did cbc and the platelets have crossed 1lakh should we get an appointment and ask with doctor about stopping Revolade(eltrombopag)? because I remember reading somewhere that after platelets cross 1lakh it should be stopped.need advice. Dose of eltrombopag should be decreased such that count should be above 50000 and not in lacs . i am having high bleeding in periods, my platelet is very low 43000 please advice how i increased my platelet If you are bleeding heavily and your platelet count is low please go to hospital . you need admission and probably platelet transfusion too. its urgent I want to know how to increase platelet count Any kind of madecin to increase platelets He has 24,000 count only U need to know your diagnosisLow platelet count is bcos of some reason U have to know that My son's platelet count is consistently low. Latest report done two days back shows 1.3 lakh platelet count. I am worried. Does it indicate something serious? What can I do to increase his platelet count. Please consult me or any other Paediatrician. will take detail history and will examine your child in detail. At time may ask you relevant investigations if necessary. All information will be used to determine exact underlying cause of problem. Depending upon cause will prescribe you treatment. Your child may need antibiotics. It is mandatory for the customer to have a prescription for the prescription medicines he/she is procuring. Valid prescription cannot be given without diagnosis.