Empadus M 5/1000ER5/1000mg

Empagliflozin + Metformin Hydrochloride is a combination of empagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor and metformin hydrochloride, a biguanide, indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both empagliflozin and metformin hydrochloride is appropriate.Empagliflozin + Metformin Hydrochloride is indicated to reduce the risk of cardiovascular death in adults with type 2 diabetes mellitus and established cardiovascular disease. However, the effectiveness of Empagliflozin + Metformin Hydrochloride on reducing the risk of cardiovascular death in adults with type 2 diabetes mellitus and cardiovascular disease has not been established. By blocking SGLT2,Empagliflozin + Metformin Hydrochloride prevents glucose from being reabsorbed and allows it to be excreted in the urine.Also work by decreasing the production of glucose in the liver and increasing the sensitivity of cells to insulin and lowers blood sugar levels.

Empagliflozin + Metformin Hydrochloride use as a treatment of adults with type 2 diabetes mellitus.

By blocking SGLT2, empagliflozin prevents glucose from being reabsorbed and allows it to be excreted in the urine and decreasing the production of glucose in the liver and increasing the sensitivity of cells to insulin .It work synergistically to lower blood sugar levels more effectively.

Adult Dose: The standard starting dose for empagliflozin + metformin hydrochloride is 5 mg of empagliflozin and 500 mg of metformin hydrochloride once daily. The dose can be gradually increased to a maximum of 25 mg of empagliflozin and 2,000 mg of metformin hydrochloride per day. Child Dose: The safety and efficacy of this medication in children under the age of 18 has not been established. Renal Dose: Before starting this combination with a renally impaired patient, assess their renal function.In patients with an eGFR below 45 mL/min/1.73 m2 is contraindicated.

Take Empagliflozin + Metformin Hydrochloride in the dose and duration prescribed by your doctor. Swallow it whole. Don't chew, crush, or break it. Empagliflozin + Metformin Hydrochloride should be taken with food.

If you forget to take yourEmpagliflozin + Metformin Hydrochloride , take them as soon as you remember. If it is almost time for your next dose, skip the missed dose and take it at the usual time. Avoid taking two doses at the same time.

• Nausea • Vomiting • Diarrhea • Headaches • Dizziness • Fatigue • Abdominal pain • Increased urination • Weight loss

[CAUTION] Empagliflozin + Metformin Hydrochloride may cause dizziness or orthostatic hypotension (low blood pressure when standing up), which can impair ability to drive.

•Type 1 diabetes •Diabetic ketoacidosis (DKA) •Severe kidney disease (eGFR < 30 mL/min/1.73 m2) •Severe liver disease •Heart failure •Active bladder infection •Recent surgery or major trauma •Hypersensitivity to empagliflozin or metformin hydrochloride History of lactic acidosis. • History of urinary tract infections or genital yeast infections •Risk of dehydration •Elderly patients

It may interact with other medications, including: •Insulin: Empagliflozin + metformin hydrochloride can increase the risk of hypoglycemia (low blood sugar) when used with insulin. •Sulfonylureas: Empagliflozin + metformin hydrochloride can also increase the risk of hypoglycemia when used with sulfonylureas, another type of medication used to treat type 2 diabetes. •Meglitinides: Empagliflozin + metformin hydrochloride can also increase the risk of hypoglycemia when used with meglitinides, another type of medication used to treat type 2 diabetes. •Thiazolidinediones: Empagliflozin + metformin hydrochloride may increase the risk of heart failure when used with thiazolidinediones, another type of medication used to treat type 2 diabetes. •Alpha-glucosidase inhibitors: Empagliflozin + metformin hydrochloride may decrease the effectiveness of alpha-glucosidase inhibitors, another type of medication used to treat type 2 diabetes. •Beta-blockers: Empagliflozin + metformin hydrochloride may mask the symptoms of hypoglycemia, such as increased heart rate and sweating, when used with beta-blockers. •ACE inhibitors: Empagliflozin + metformin hydrochloride may increase the risk of hypotension (low blood pressure) when used with ACE inhibitors. •ARBs: Empagliflozin + metformin hydrochloride may increase the risk of hypotension when used with ARBs. •Diuretics: Empagliflozin + metformin hydrochloride may increase the risk of dehydration when used with diuretics. •Steroids: Empagliflozin + metformin hydrochloride may increase the risk of hyperglycemia (high blood sugar) when used with steroids. •Thyroid hormones: Empagliflozin + metformin hydrochloride may increase the risk of hypoglycemia when used with thyroid hormones.

[UNSAFE] It is unsafe to consume Empagliflozin + Metformin Hydrochloride with alcohol.

[UNSAFE] Empagliflozin + Metformin Hydrochloride should not be used during pregnancy.

[UNSAFE] Empagliflozin + Metformin Hydrochloride should not be used during breastfeeding.

[CONSULT YOUR DOCTOR] It is important to talk to your doctor about the risks and benefits of taking Empagliflozin + Metformin Hydrochloride before starting treatment. Empagliflozin + Metformin Hydrochloride should not be given to patients with serious kidney disease. [CAUTION] Empagliflozin + Metformin Hydrochloride may not be suitable for patients with severe liver impairment.

Store below 30°C temperature, protected from light & moisture. Keep out of the reach of children.

Q: Who should not takeEmpagliflozin + Metformin Hydrochloride? Ans:Empagliflozin + Metformin Hydrochloride should not be taken by people with type 1 diabetes, diabetic ketoacidosis (DKA), severe kidney disease, severe liver disease, heart failure, active bladder infection, or recent surgery or major trauma. Q; How is Empagliflozin + Metformin Hydrochloride taken? Ans:Empagliflozin + Metformin Hydrochloride is usually taken once daily with or without food. Q:Can Empagliflozin + Metformin Hydrochloride be used to treat type 1 diabetes? Ans:No, Empagliflozin + Metformin Hydrochloride cannot be used to treat type I diabetes. Empagliflozin plus metformin hydrochloride is only approved for use in adults with type 2 diabetes.