Flumelone N

• Allergic and Inflammatory Eye Conditions: Used for treatment of conjunctivitis (sticky eyes) due to organisms sensitive to neomycin.
• Post-operative Infection Prevention: Used before and after surgery where there is a possibility of infection.

Fluorometholone suppresses the migration of polymorphonuclear leukocytes and reversal of increased capillary permeability thus decreasing inflammation. Neomycin is an aminoglycoside antibiotic. It binds to 30S ribosomal subunits of bacterial ribosome thus inhibiting protein synthesis and generating errors in genetic code transcription causing cell death.

Adult Dose (Ophthalmic):

• Instill 1-2 drops 2-4 times/day in the affected eye.
• May increase dose to 4 hrly in severe cases during the initial 24-48 hr.

Side Effects:

• Elevated intraocular pressure
• Optic nerve damage
• Postsubcapsular cataract formation
• Delayed wound healing
• Uveitis
• Corneal ulcers
• Secondary ocular infections
• Rarely systemic hypercorticoidism

Use in Pregnancy: May be unsafe; animal studies have shown harmful effects; consult your doctor before use.

Precautions:

• Glaucoma (check intraocular pressure periodically)
• History of herpes simplex, fungal or bacterial infections
• Not to be used in mustard gas keratitis and Sjogren's keratoconjunctivitis
• May cause corneal and scleral thinning which may lead to perforation
• Use of steroids after cataract surgery may prolong healing time
• Safety not established in children under 2 years

Overdose: Limited information on topical overdose; excessive use may cause eye irritation.

Storage: Store at or below 25 degree C. Do not freeze. Do not use 30 days after first opening.