৳ 3,000/unit
Pack: ৳ 3,000
৳ 3,000/unit
Pack: ৳ 3,000
At a glance
Isoflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia in major surgical procedures.
Indications
- Induction and maintenance of general anesthesia
Pharmacology
Isoflurane is a nonflammable liquid and a general inhalation anesthetic drug. Induction of and recovery from isoflurane anesthesia are rapid. It causes reversible loss of consciousness and pain sensations, suppression of voluntary motor activity, modification of autonomic reflexes, and depression of the respiratory and cardiovascular system. The minimum alveolar concentration (MAC) decreases with increasing patient age.
Dosage
Adult Dose (Inhalation):
- Induction: 1.5-3% (produces surgical anesthesia in 7-10 minutes)
- Maintenance: 1-2.5% with nitrous oxide; 1.5-3.5% with oxygen alone
Child Dose: Safety & efficacy not established
Side effects
Common Side Effects:
- Shivering
- Nausea
- Vomiting
- High grade fever
- Decreased blood pressure
- Irregular heartbeat
Others: Delirium, agitation, breath holding, cough, laryngospasm, nodal arrhythmia
Use in pregnancy
Use in Pregnancy: No adequate and well-controlled studies in pregnant women; animal studies have shown harmful effects; doctor will weigh benefits and risks.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Isoflurane may cause an increase in intracranial pressure which can affect ability to drive
- Caution in patients with known or suspected susceptibility to malignant hyperthermia
- Hepatic dysfunction has been reported with halogenated inhalational anesthetics
- QTc prolongation may occur
- Additional cardiac monitoring in patients with coronary artery disease
- Caution in hypovolemic, hypotensive or otherwise hemodynamically compromised patients
Overdose effects
Overdose: Stop drug administration, establish a clear airway and initiate assisted or controlled ventilation with pure oxygen; monitor cardiovascular function.
Storage conditions
Store below 25°C in a dry place, protected from light; keep out of reach of children.