Genazopt Plus Eye Drop
1%+0.2%Rx৳ 550/unit
Pack: ৳ 550
৳ 550/unit
Pack: ৳ 550
At a glance
Brinzolamide 1% + Brimonidine Tartrate 0.2% Eye Prep is a combination medication used for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Brinzolamide reduces aqueous humour secretion and Brimonidine reduces aqueous humour production and increases uveoscleral outflow, together lowering intraocular pressure.
Indications
- Open-angle glaucoma
- Ocular hypertension
Pharmacology
Brinzolamide (carbonic anhydrase inhibitor) and Brimonidine Tartrate (alpha-2 adrenergic receptor agonist) each decrease elevated intraocular pressure. Brinzolamide inhibits carbonic anhydrase in the ciliary processes to decrease aqueous humour secretion. Brimonidine Tartrate has a dual mechanism of action by reducing aqueous humour production and increasing uveoscleral outflow.
Dosage
Adults: Instill 1 drop in the affected eye(s) three times daily. Shake well before use.
Children (2 years and older): Instill 1 drop in the affected eye(s) 2-3 times daily.
Children under 2 years: Contraindicated.
Note: If more than one topical ophthalmic drug is being used, administer at least 5 minutes apart. Apply pressure on the corner of the eye (close to the nose) for about 1 minute after instillation (to reduce systemic absorption). Use within 1 month of opening.
Side effects
Common (approximately 3-5% of patients): Blurred vision, eye irritation, dysgeusia (bad taste), dry mouth, eye allergy.
Brinzolamide-related (5-10%): Blurred vision, bitter/sour/unusual taste. (1-5%): Blepharitis, dermatitis, dry eye, foreign body sensation, headache, hyperemia, ocular discharge, ocular discomfort, keratitis, eye pain, pruritus, rhinitis.
Brimonidine-related (10-30%): Dry mouth, ocular hyperemia, burning and stinging, headache, blurred vision, foreign body sensation, fatigue/drowsiness, conjunctival follicles, ocular allergic reactions, ocular pruritus.
Avoid driving or operating machinery until you know how this medicine affects you.
Use in pregnancy
May be unsafe during pregnancy (Category C). Limited human studies available; animal studies have shown harmful effects on the developing baby. Use during pregnancy only if potential benefit justifies potential risk to the fetus.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May cause blurred or abnormal vision after use (especially at night or in reduced lighting); do not drive or operate machinery until vision is clear.
- Apply pressure on the corner of the eye (close to the nose) for about 1 minute after instillation (to reduce systemic absorption and minimize drug transfer to breast milk).
- Use within 1 month of opening.
- Remove soft contact lenses before use and wait at least 15 minutes before reinserting.
- Brinzolamide is a sulfonamide; although administered topically, it is absorbed systemically. Serious sulfonamide-related reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia) may occur.
- Brimonidine may potentiate syndromes associated with vascular insufficiency (depression, cerebral/coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension, thromboangiitis obliterans); caution required.
- Not recommended in severe renal impairment.
Overdose effects
Oral overdose: Electrolyte imbalance, acidotic state, and possible nervous system effects may occur. Monitor serum electrolytes (especially potassium) and blood pH. Brimonidine overdose may cause hypotension. Treatment: Supportive and symptomatic therapy; maintain a patent airway.
Storage conditions
Store at room temperature, protected from light. Do not touch dropper tip to any surface. Do not use more than 1 month after first opening. Shake well before use. Do not freeze.