Xolamid B1%+0.2%
Rx- Company:
- Opsonin Pharma Limited
- Dosage form:
- Eye Drop
- Pack size:
- 5ml bot
৳ 550/unit
Pack: ৳ 550
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At a glance
Brinzolamide 1% + Brimonidine Tartrate 0.2% Eye Prep is a combination medication used for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Brinzolamide reduces aqueous humour secretion and Brimonidine reduces aqueous humour production and increases uveoscleral outflow, together lowering intraocular pressure.
Indications
- Open-angle glaucoma
- Ocular hypertension
Dosage
Adults: Instill 1 drop in the affected eye(s) three times daily. Shake well before use.
Children (2 years and older): Instill 1 drop in the affected eye(s) 2-3 times daily.
Children under 2 years: Contraindicated.
Note: If more than one topical ophthalmic drug is being used, administer at least 5 minutes apart. Apply pressure on the corner of the eye (close to the nose) for about 1 minute after instillation (to reduce systemic absorption). Use within 1 month of opening.
Side effects
Common (approximately 3-5% of patients): Blurred vision, eye irritation, dysgeusia (bad taste), dry mouth, eye allergy.
Brinzolamide-related (5-10%): Blurred vision, bitter/sour/unusual taste. (1-5%): Blepharitis, dermatitis, dry eye, foreign body sensation, headache, hyperemia, ocular discharge, ocular discomfort, keratitis, eye pain, pruritus, rhinitis.
Brimonidine-related (10-30%): Dry mouth, ocular hyperemia, burning and stinging, headache, blurred vision, foreign body sensation, fatigue/drowsiness, conjunctival follicles, ocular allergic reactions, ocular pruritus.
Avoid driving or operating machinery until you know how this medicine affects you.
Precautions & warnings
- May cause blurred or abnormal vision after use (especially at night or in reduced lighting); do not drive or operate machinery until vision is clear.
- Apply pressure on the corner of the eye (close to the nose) for about 1 minute after instillation (to reduce systemic absorption and minimize drug transfer to breast milk).
- Use within 1 month of opening.
- Remove soft contact lenses before use and wait at least 15 minutes before reinserting.
- Brinzolamide is a sulfonamide; although administered topically, it is absorbed systemically. Serious sulfonamide-related reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia) may occur.
- Brimonidine may potentiate syndromes associated with vascular insufficiency (depression, cerebral/coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension, thromboangiitis obliterans); caution required.
- Not recommended in severe renal impairment.