৳ 8,501/unit
Pack: ৳ 8,501
৳ 8,501/unit
Pack: ৳ 8,501
At a glance
Follitropin Alfa is a recombinant FSH preparation used for ovulation induction in women and spermatogenesis stimulation in men.
Indications
- Induction of ovulation: in oligo-anovulatory infertile women for whom the cause of infertility is functional and not due to primary ovarian failure.
- Development of multiple follicles: as part of an assisted reproductive technology (ART) cycle.
- Induction of spermatogenesis: in infertile men with azoospermia and primary or secondary hypogonadotropic hypogonadism.
Pharmacology
Follitropin alfa is a human FSH preparation of recombinant DNA origin. It stimulates ovarian follicular growth in women who do not have primary ovarian failure. To bring about final maturation of the follicle and ovulation, hCG must be given. Follitropin Alfa stimulates spermatogenesis in men with hypogonadotropic hypogonadism when administered with hCG.
Dosage
Ovulation Induction (Women):
- First cycle starting dose: 75 IU/day for 14 days SC.
- Individualize doses after 14 days.
- Maximum 300 IU/day.
Multiple Follicles in ART (Women):
- First cycle starting dose: 150 IU/day SC.
- Adjust by 75-150 IU every 3-5 days.
- Maximum 450 IU/day.
Males with Hypogonadotropic Hypogonadism and Azoospermia:
- Pre-treat with hCG (1,000-2,250 USP units 2-3 times weekly) for 3-6 months.
- After testosterone normalization: 150 IU three times weekly + hCG 1,000 USP units three times weekly.
* Use as directed by the registered physician
Side effects
Common Side Effects (≥5%):
- Ovarian cyst
- Headache
- Abdominal pain
- Ovarian hyperstimulation syndrome (OHSS)
- Nausea
- Flatulence
- Injection site pain
- Fatigue
- Gynecomastia
Serious Side Effects: Severe OHSS, ovarian torsion, thromboembolism, anaphylaxis.
Use in pregnancy
Use in Pregnancy: Not indicated in pregnant women. The incidence of congenital malformations after some ART may be slightly higher than spontaneous conception.
Pregnancy Category: X — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- If hypersensitivity or anaphylaxis occurs, discontinue and initiate appropriate therapy.
- Ovarian hyperstimulation syndrome (OHSS) - if serious, stop HCG and may require hospitalization.
- Pulmonary and vascular complications - monitor for thromboembolic events.
- Risk of multiple gestations - inform patient before starting therapy.
- Increased risk of ectopic pregnancy - early ultrasound confirmation important.
Overdose effects
Overdose: Too high a dosage may lead to ovarian hyperstimulation. No specific antidote. Give supportive care.
Storage conditions
Storage: Lyophilized Multi-Dose vials may be stored refrigerated or at room temperature (2°-25°C).