৳ 1/unit
Pack: ৳ 1
৳ 1/unit
Pack: ৳ 1
At a glance
Indapamide + Perindopril Erbumine combination is used for the treatment of essential hypertension where blood pressure is not adequately controlled on perindopril alone.
Indications
- Essential hypertension (where blood pressure is not adequately controlled on perindopril alone)
Pharmacology
Perindopril is a nonsulphydryl ACE inhibitor that is rapidly hydrolysed to perindoprilat, its principal active metabolite. ACE catalyses the conversion of angiotensin I to the vasoconstrictor angiotensin II. Inhibition of ACE activity leads to decreased levels of angiotensin II, resulting in decreased vasoconstriction and decreased aldosterone secretion. Indapamide is a sulphonamide derivative with an indole ring that inhibits sodium reabsorption in the cortical diluting segment, increasing urinary excretion of sodium and chlorides.
Dosage
Adult Dose (Oral):
- 1-2 tablets daily in the morning (before a meal)
- In case of renal insufficiency, start with an adequate dose
Renal Dose: CrCl <30 mL/min: Avoid use; CrCl 30-60: Dose adjustment may be needed
Side effects
Common Side Effects:
- Nausea
- Diarrhea
- Stomach pain
- Constipation
- Vomiting
- Headache
- Vertigo
- Dizziness
- Altered vision
- Numbness
- Ringing in ear
- Breathlessness
- Indigestion
- Allergic reaction
- Skin rash
- Itching
- Cramps
- Fatigue
Others: Persistent dry cough, angioedema, rash, dyspepsia, sleep disturbance, asthenia, dry mouth, hypotension
Use in pregnancy
Use in Pregnancy: Unsafe during pregnancy; definite evidence of risk to developing baby; not recommended during pregnancy.
Precautions & warnings
Precautions:
- Indapamide + Perindopril may affect your ability to drive (dizziness, weakness)
- Inform doctor about cough or throat irritation that doesn't go away
- May cause dehydration; drink plenty of fluids; inform doctor if extreme thirst, muscle weakness or very dry mouth develops
- If dizziness occurs, rise slowly from sitting or lying position
- Not safe during pregnancy (may cause birth defects or fetal death)
- Caution in renal impairment, renal artery stenosis, heart failure, gout, diabetes, liver cirrhosis, elderly, atherosclerosis, idiopathic or hereditary angioedema
Overdose effects
Overdose: Hypotension, nausea, vomiting, cramps, dizziness, sleepiness, mental confusion, oliguria (may progress to anuria), salt and water disturbances (low sodium, low potassium); gastric lavage or activated charcoal; monitor and maintain fluid and electrolyte balance.
Storage conditions
Keep below 30°C temperature, away from light & moisture; keep out of reach of children.