৳ 25/unit
Pack: ৳ 250
৳ 25/unit
Pack: ৳ 250
At a glance
Elobixibat is a medicine used for the treatment of chronic idiopathic constipation (except for constipation associated with organic diseases). It inhibits ileal bile acid transporter (IBAT) to increase bile acid in the intestinal lumen and enhance colonic motility.
Indications
- Chronic idiopathic constipation (except for constipation associated with organic diseases)
Pharmacology
Elobixibat inhibits bile acid reabsorption via IBAT expressed on the epithelial cells of the terminal ileum, increasing the amount of bile acid passing into the large intestinal lumen. Bile acid promotes secretion of water and electrolytes and enhances colonic motility.
Dosage
Adult Dose: 10 mg once daily before meal. Dosage may be adjusted based on patient's symptoms but must not exceed 15 mg per day.
Elderly Dose: Caution should be exercised, such as reducing the dose, due to reduced physiological functions.
Side effects
Common Side Effects:
- Abdominal pain
- Diarrhea
- Nausea
- Abdominal discomfort
- Soft faeces
- Abdominal distension
- Liver function test abnormalities
Use in pregnancy
Should be used in pregnant women only if expected therapeutic benefits outweigh possible risks.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Elobixibat may cause abdominal pain or diarrhea; dose reduction, drug withdrawal or discontinuation should be considered based on symptoms.
- May not achieve expected efficacy in serious liver disorder (due to biliary obstruction or reduced bile acid secretion).
- Regular evaluation of need for continuing treatment to avoid aimless administration.
Overdose effects
No data on overdose. Do not exceed indicated dosing. Actively monitor for timely response.
Storage conditions
Do not store above 25°C. Protect from light. Keep out of reach of children.