৳ 850/unit
Pack: ৳ 8,500
৳ 850/unit
Pack: ৳ 8,500
At a glance
Lefamulin is an antibiotic used for the treatment of community-acquired bacterial pneumonia (CABP). It is a first-in-class semi-synthetic pleuromutilin antibiotic that works by inhibiting bacterial protein synthesis.
Indications
- Community-acquired bacterial pneumonia (CABP) - caused by susceptible microorganisms: Streptococcus pneumoniae, Staphylococcus aureus (methicillin-susceptible), Haemophilus influenzae, Legionella pneumophila, Mycoplasma pneumoniae, Chlamydophila pneumoniae
Pharmacology
Lefamulin inhibits bacterial protein synthesis by binding to the peptidyl transferase center of the 50S ribosomal subunit. It works through a novel mechanism that is effective against resistant bacteria that cause pneumonia.
Dosage
Adult Dose:
- Injection (IV): 150 mg every 12 hours, 60-minute IV infusion, 5-7 days
- Tablet (PO): 600 mg every 12 hours, 5 days
- Dose adjustment required for severe hepatic impairment (IV: 150 mg every 24 hours; Tablets: not recommended)
Side effects
Common Side Effects:
- Diarrhea
- Nausea
- Injection site reactions
- Elevated liver enzymes
- Vomiting
- Potential for QT interval prolongation
Use in pregnancy
Use in Pregnancy: Animal studies have shown fetal harm; pregnant women should be advised of potential risks. Women who could become pregnant should use effective contraception during treatment and for 2 days after the final dose.
Precautions & warnings
- Potential for QT interval prolongation - avoid in patients with prolonged QT, ventricular arrhythmias, or taking QT-prolonging drugs
- Clostridioides difficile-associated diarrhea (CDAD) - reported with nearly all systemic antibacterial agents
- Dose adjustment needed for severe hepatic impairment
Overdose effects
Overdose treatment: observation and general supportive measures; empty stomach; maintain hydration and monitor electrolytes; ECG monitoring recommended; hemodialysis is not effective.
Storage conditions
Injection: Store refrigerated (2-8°C); do not freeze; protect from light. Tablets: Do not store above 30°C; do not refrigerate or freeze; store in a dry place.