৳ 12/unit
Pack: ৳ 96
৳ 12/unit
Pack: ৳ 96
At a glance
Lithium Carbonate is used in the treatment of bipolar disorder and mania. It reduces the frequency and intensity of manic episodes and helps stabilize mood.
Indications
- Mania - treatment and prophylaxis
- Bipolar disorder - treatment and prophylaxis
- Recurrent unipolar depression
Pharmacology
Lithium inhibits glycogen synthase kinase 3 and inositol phosphatases, modulates glutamate receptors, and alters catecholamine metabolism in neurons.
Dosage
Adult Dose (Oral):
- Mania/Bipolar/Recurrent depression: 400-1,200 mg/day in 1-2 divided doses
- Serum lithium monitoring: 0.6-1.2 mEq/L (max 1.5 mEq/L)
- Renal impairment: CrCl 10-50: 50-75% of normal dose; CrCl <10: 25-50%
Side effects
Common Side Effects:
- Tremor
- Slurred speech
- Uncoordinated body movements
- Nausea
- Acne
- Increased white blood cell count
- Memory impairment
- Hair loss
- Goiter (enlarged thyroid)
- Skin rash
- Increased thirst
- Weight gain
- Polyuria
- Diarrhea
Use in pregnancy
Use in Pregnancy: Lithium Carbonate is unsafe during pregnancy (Category D); definite evidence of risk to the fetus. Use only in life-threatening situations with doctor's advice.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Monitor lithium blood levels, thyroid, and kidney function regularly
- May cause diarrhea and dehydration; drink plenty of water and use normal amounts of salt
- Inform doctor if starting or stopping a low-salt diet
- Monitor weight during treatment (may cause weight gain)
- Caution when driving or doing activities requiring concentration (may cause drowsiness, tiredness, dizziness)
Overdose effects
Overdose: discontinue lithium, serum estimations every 6 hours; if serum lithium >4 mmol/L or clinical deterioration, initiate peritoneal or hemodialysis.
Storage conditions
Store below 30°C, away from light and moisture; keep out of reach of children.