Maxidim IV/IM500mg/vial

Ceftazidime is an antibiotic medicine used to treat bacterial infections in your body. It is effective in infections of the brain, lungs, ear, urinary tract, skin and soft tissues, bones and joints, blood and heart. It is also used to prevent infections during surgery. Ceftazidime fights and stops the growth of many types of bacteria. This helps to improve your symptoms and cure the underlying infection. It is given as a drip (intravenous infusion) or as an injection directly into a vein or a muscle under the supervision of a healthcare professional. Your doctor will decide the correct dose for you. You should use this medicine regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping the medicine too early may lead to the infection returning or worsening. The most common side effects of this medicine include rash and diarrhoea. Some people may develop temporary redness or pain at the site of injection. These side effects are usually mild but let your doctor know if they bother you or last more than a few days. Before using it, you should tell your doctor if you are allergic to any antibiotics, and if you have any liver or kidney problems. You should also let your healthcare team know all other medicines you are taking as they may affect, or be affected by this medicine. Pregnant and breastfeeding mothers should consult their doctor before using it. Ceftazidime is an antibiotic. It kills the bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.

• Bacterial infections

Ceftazidime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

Adult Dose: Bone & Joint Infections 2 g IV q12hr Gynecologic & Intra-abdominal Infections, Meningitis, Complicated Pneumonia, Life-Threatening Infections 2 g IV q8hr Pulmonary Infections Infections caused by Pseudomonas spp in patients with cystic fibrosis who have healthy renal function 30-50 mg/kg IV q8hr; not to exceed 6 g/day Uncomplicated Pneumonia 0.5-1 g IV q8hr Mild Skin/Skin Structure Infections 0.5-1 g IV or IM q8hr Urinary Tract Infections Complicated: 500 mg IV or IM q8-12hr Uncomplicated: 250 mg IV or IM q12hr Elderly: >80 yr Max: 3 g daily. Child Dose: Child: IV, IM 90–150 mg/kg/day q8h IV 200–300 mg/kg/day for serious Pseudomonas infection (max 8–12 g/day) q8h Renal Dose: Renal impairment: Loading dose: 1 g; maintenance doses based on CrCl. May need to increase doses by 50% in severe infections. Peritoneal dialysis: Loading dose is followed by 500 mg every 24 hr; may add ceftazidime to the dialysis fluid (usually 125-250 mg for 2 litres of dialysis fluid). Haemodialysis: Admin loading dose then 0.5-1 g after each dialysis period. CrCl (ml/min) 31-50 1 g every 12 hr. 16-30 1 g every 24 hr. 6-15 500 mg every 24 hr. <5 500 mg every 48 hr.

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Ceftazidime, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Rash • Allergic reaction • Injection site reaction • Diarrhea

[UNSAFE] Ceftazidime may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Your doctor has prescribed Ceftazidime to cure your infection and improve your symptoms. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection harder to treat. Discontinue Ceftazidime and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing. Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools. Avoid consuming alcohol while taking Ceftazidime as it may cause increased side effects.

Hypersensitivity to cephalosporins.

May increase nephrotoxicity of aminoglycosides. May diminish therapeutic effect of BCG, typhoid vaccine, Na picosulfate. May increase anticoagulant effect of vit K antagonists (e.g. warfarin). May increase serum level w/ probenecid.

[SAFE] Consuming alcohol with Ceftazidime does not cause any harmful side effects.

[SAFE IF PRESCRIBED] Ceftazidime is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

[SAFE IF PRESCRIBED] Ceftazidime is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby. Avoid prolonged use of Ceftazidime, since it may have possible effects such as rash and diarrhea.

[CAUTION] Ceftazidime should be used with caution in patients with kidney disease. Dose adjustment of Ceftazidime may be needed. Please consult your doctor. [CAUTION] Ceftazidime should be used with caution in patients with severe liver disease. Dose adjustment of Ceftazidime may be needed. Please consult your doctor.

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