Methovate R
Rx৳ 30.09/unit
Pack: ৳ 30.09
৳ 30.09/unit
Pack: ৳ 30.09
At a glance
Betamethasone 0.05% + Lidocaine Hydrochloride 2.5%+ Phenylephrine Hydrochloride 0.1% (Rectal prep) is a combination preparation used for the relief of discomfort, pain, itchiness, and irritation around the anus and for the treatment of haemorrhoids (piles).
Indications
- Discomfort, pain, itchiness or irritation around the anus
- Haemorrhoids (Piles)
Pharmacology
Betamethasone is a corticosteroid with mainly glucocorticoid activity. It prevents and controls inflammation by controlling the rate of protein synthesis, depressing the migration of polymorphonuclear leukocytes and fibroblasts, and reversing capillary permeability and lysosomal stabilisation.
Lidocaine is an amide-type local anesthetic that reversibly blocks the initiation and conduction of nerve impulses by interfering with the flux of sodium ions through the neuronal membrane.
Phenylephrine is an alpha adrenergic agonist that elicits localized vasoconstriction and decreases inflammation.
Dosage
Adults: Apply to the perianal region or rectally. May apply up to 2-4 times daily, especially at night, in the morning, or after bowel movement that may exacerbate hemorrhoid(s).
Side effects
- Topical application to the eye: Corneal ulcers, raised IOP and reduced visual acuity
- Intradermal injection: Local hypopigmentation of deeply pigmented skin
- Intra-articular injection: Joint damage, fibrosis, especially in load bearing joints
Use in pregnancy
[CONSULT YOUR DOCTOR] Limited safety data during pregnancy. Topical corticosteroids may cause fetal abnormalities in animals. Use only if clearly needed and under medical supervision.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Caution in uncontrolled diabetes, peptic ulcer, osteoporosis, psychosis, psychoneurosis
- Caution in congestive heart failure, hypertension, epilepsy, chronic renal failure, elderly patients
- Regular monitoring required for patients on long-term therapy
- Withdraw gradually
- Caution in glaucoma, hypothyroidism, cirrhosis, ocular herpes simplex, ulcerative colitis
- Caution during pregnancy and lactation
Overdose effects
Overuse may cause systemic absorption and corticosteroid side effects. Consult a doctor if symptoms occur.
Storage conditions
Store below 30°C, away from light and moisture. Keep out of reach of children.