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At a glance

Mifepristone is an anti-progestational steroid used for medical termination of pregnancy.

Indications
  • Medical termination of pregnancy (up to 70 days)
  • Cervical softening and dilatation
  • Preparation for prostaglandin analogues
  • Labor induction for expulsion of dead fetus
Pharmacology

Mifepristone binds to intracellular progesterone receptor and competitively inhibits progesterone attachment.

Dosage

Adult Dose:

  • Pregnancy Termination: 200 mg single oral dose (Day 1); followed by Misoprostol 800 mcg after 24-48 hours
  • Cervical Softening: 200 mg
  • Prostaglandin Preparation: 600 mg
  • Fetal Death Expulsion: 600 mg/day for 2 days
Side effects

Common Side Effects:

  • Nausea and vomiting
  • Uterine contractions and cramping
  • Diarrhea
  • Vaginal bleeding
  • Dizziness
  • Skin rash and urticaria
Use in pregnancy

Use in Pregnancy: Highly unsafe (Category X). Contraindicated during pregnancy.

Pregnancy Category: X — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Do not use if suspected ectopic pregnancy
  • Caution in long-term corticosteroid therapy
  • Contraindicated in adrenal failure
  • Caution in bleeding disorders
  • Contraindicated in pregnancy and lactation
Overdose effects

Single doses up to 2 gm caused no adverse reactions. Massive overdose may cause signs of adrenal failure.

Storage conditions

Store in a cool and dry place protected from light below 25°C.

Mifepristone — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.