৳ 8.07/unit
Pack: ৳ 80.70
৳ 8.07/unit
Pack: ৳ 80.70
At a glance
Midazolam is a benzodiazepine used for sedation or conscious sedation before diagnostic or therapeutic procedures.
Indications
- Conscious sedation before diagnostic or therapeutic procedures
- Short-term treatment of insomnia
- Preoperative sedation
Pharmacology
Midazolam's actions are mediated through GABA the major inhibitory neurotransmitter in the CNS. Benzodiazepines increase GABA activity producing sedative effects and relaxing skeletal muscles.
Dosage
Adult Dose (Oral):
- Insomnia: 7.5-15 mg at bedtime
- Elderly: 7.5 mg at bedtime
- Pre-medication: 15 mg 30-60 minutes before procedure
Parenteral:
- Preoperative Sedation IM: 0.07-0.1 mg/kg
- Endoscopic Procedures IV: 2.5 mg
- Anesthesia IV: 10-15 mg
Child Dose: 0.15-0.20 mg/kg IM
Side effects
Common Side Effects:
- Nasal discomfort
- Throat irritation
- Headache
- Drowsiness
- Confusion
- Muscle weakness
Serious Side Effects:
- Respiratory depression
- Apnea
- Blood pressure variations
Use in pregnancy
Unsafe during pregnancy (Category D). Use only in life-threatening situations.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- High habit-forming potential
- Caution while driving (may cause dizziness)
- Avoid alcohol
- Do not stop abruptly
- Caution in pregnancy and lactation
Overdose effects
Extreme overdosage may lead to coma areflexia cardiorespiratory depression and apnea. Can be controlled with flumazenil.
Storage conditions
Protect from light and moisture. Store in cool and dry place. Keep out of reach of children.