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Lomefloxacin is an antibiotic, used in the treatment of bacterial infections. It is also used in treating infections of the urinary tract, nose, throat, skin and soft tissues and lungs (pneumonia). It cures the infection by stopping the further growth of the causative microorganisms. Lomefloxacin should be used in the dose and duration as advised by your doctor. It may be taken with or without food, preferably at a fixed time. Avoid taking antacids containing aluminum or magnesium within 2 hours before or 2 hours after you take this medicine. Taking antacids, sucralfate, or vitamin or mineral supplements too close to a dose of this medicine, can greatly decrease the effects of the antibiotic. Do not skip any doses and finish the full course of treatment even if you feel better. You should not take a double dose to make up for a missed dose. Simply take the next dose as planned. You may have a headache, dizziness, nausea, and constipation as side effects of this medicine. These are usually temporary and resolves on its own, but please consult your doctor if it bothers you or persists for a longer duration. Diarrhea may also occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools. You should not take this medicine if you are allergic to any of its ingredients. Special care should be taken in people with kidney problems while taking this medicine. Lomefloxacin is an antibiotic medicine to be taken by mouth. It works by stopping the action of a bacterial enzyme called DNA-gyrase. This prevents the bacterial cells from dividing and repairing, thereby killing them.

• Bacterial infections

Lomefloxacin promotes breakage of double-stranded DNA in susceptible organisms and inhibits DNA gyrase, which is essential in reproduction of bacterial DNA.

Adult Dose: Oral Acute bacterial exacerbation of chronic bronchitis Adult: 400 mg once daily for 10 days. Uncomplicated urinary tract infections Adult: 400 mg once daily. Due to E. coli: For 3 successive days. Due to K. pneumoniae, P. mirabilis or S. saprophyticus: For 10 successive days. Complicated urinary tract infections Adult: Due to E. coli, K. pneumoniae, P. mirabilis or P. aeruginosa: 400 mg once daily for 14 successive days. Prophylaxis of surgical infections Adult: 400 mg as a single dose 1-6 hr before procedure. Renal Dose: Renal impairment: Haemodialysis: Initially, 400 mg daily. Maintenance: 200 mg daily. CrCl (ml/min) Dosage Recommendation 10-40 Initially, 400 mg daily. Maintenance: 200 mg daily.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lomefloxacin may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Lomefloxacin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Headache • Dizziness • Nausea • Constipation • Diarrhea

[SAFE] Lomefloxacin does not usually affect your ability to drive. Your doctor has prescribed Lomefloxacin to cure your infection and improve symptoms. Do not skip any doses and finish the full course of treatment even if you feel better. Discontinue Lomefloxacin and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing. Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools. Notify your doctor if you feel pain in your tendons, numbness, or tingling sensations. Inform your doctor if you are pregnant or planning to conceive or breastfeeding.

Hypersensitivity to the drug or other quinolones; children <18 yr; pregnancy and lactation.

Reduced bioavailability with sucralfate, antacids containing magnesium or aluminium, vitamin or mineral supplements containing iron. Increased serum levels with cimetidine. Potential increase in serum levels of ciclosporin. Renal elimination reduced with probenecid. Potentially Fatal: Increased risk of ventricular arrhythmias with class IA (quinidine, procainamide) or class III (amiodarone, sotalol) antiarrhythmic agents.

[SAFE] Consuming alcohol with Lomefloxacin does not cause any harmful side effects.

[CONSULT YOUR DOCTOR] Lomefloxacin may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Lomefloxacin is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[CAUTION] Lomefloxacin should be used with caution in patients with kidney disease. Dose adjustment of Lomefloxacin may be needed. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Lomefloxacin in patients with liver disease. Please consult your doctor.

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