৳ 25/unit
Pack: ৳ 250
৳ 25/unit
Pack: ৳ 250
At a glance
Pregabalin is used for neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, neuropathic pain associated with spinal cord injury, and as adjunctive therapy for partial-onset seizures. It is a structural derivative of GABA that binds to the α2-δ subunit of calcium channels, reducing neurotransmitter release.
Indications
- Neuropathic pain associated with diabetic peripheral neuropathy
- Postherpetic neuralgia
- Adjunctive therapy for partial-onset seizures (1 month and older)
- Fibromyalgia
- Neuropathic pain associated with spinal cord injury
Pharmacology
Pregabalin binds with high affinity to the α2-δ subunit of voltage-gated calcium channels in CNS tissues. It modulates calcium channel activity and reduces the release of several neurotransmitters including glutamate, norepinephrine, serotonin, and dopamine, producing analgesic and anticonvulsant effects.
Dosage
Adult Dose (Oral):
- Diabetic neuropathy: 50 mg three times daily initially; increase to 100 mg three times daily within 1 week; max 300 mg/day
- Postherpetic neuralgia: 150 mg/day initially; increase to 300 mg/day; max 600 mg/day
- Fibromyalgia: 150 mg/day initially; maintenance 300-450 mg/day
- Spinal cord injury: 150 mg/day initially; 300-600 mg/day
- Partial seizures: 150 mg/day initially; 300 mg/day; max 600 mg/day
- CR tablet: 165 mg once daily; increase to 330 mg/day; max 660 mg/day
Renal Impairment Dose: CrCl 30-<60: 75 mg/day (max 300 mg/day); CrCl 15-<30: 25-50 mg/day (max 150 mg/day); CrCl <15: 25 mg/day (max 75 mg/day)
Side effects
Common Side Effects:
- Dizziness
- Somnolence
- Dry mouth
- Edema
- Blurred vision
- Weight gain
- Thinking abnormal (difficulty with concentration/attention)
Use in pregnancy
Use in Pregnancy: May be unsafe during pregnancy; animal studies have shown harmful effects; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May affect driving ability; do not drive if drowsy or dizzy
- Discontinue if angioedema (swelling of throat, head, neck) occurs
- Discontinue if hypersensitivity reactions (hives, dyspnea) occur
- Risk of suicidal thoughts or behavior; monitor
- Respiratory depression may occur with concomitant CNS depressants or underlying respiratory impairment
Overdose effects
Overdose: Reduced consciousness, depression/anxiety, confusional state, agitation, seizures, heart block; no specific antidote; emesis or gastric lavage, supportive care, monitoring of vital signs.
Storage conditions
Store in a cool and dry place (below 30°C), protected from light and moisture; keep out of reach of children.