Newbain IM/IV Injection20mg/2ml

Nalbuphine Hydrochloride is a pain relieving medicine. It is used to treat moderate to severe pain. It is also used as a premedication before surgery. This medicine is generally used when alternative medicines are ineffective or inadequate. Nalbuphine Hydrochloride is generally administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. The most common side effects of this medicine include injection site reactions (such as pain, redness, and swelling), nausea, vomiting, sweating a lot, and tiredness. If any of these side effects persist or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms. Before using it, you should let your doctor know if you have a history of stomach ulcers, heart diseases, high blood pressure, and liver or kidney disease. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine. If you are pregnant or breastfeeding, it is important to ask the advice of your doctor before taking this medicine. Your doctor may also regularly monitor your kidney function, liver function, and levels of blood components if you are taking this medicine for long-term treatment. Nalbuphine Hydrochloride is an opioid analgesic (pain reliever) which works by blocking transmission of pain signals to the brain to lower pain perception.

• Moderate to severe pain

Nalbuphine is a phenanthrene derivative opioid analgesic with mixed opioid agonist and antagonist activity. It inhibits the ascending pain pathways, altering the perception of and response to pain by binding to opiate receptors in the CNS. It also produces generalised CNS depression.

Adult Dose: Parenteral Moderate to severe pain Adult: IM/IV/SC: 10-20 mg 3-6 hrly as required. Non-opioid-tolerant patients: Max single dose: 20 mg. Max daily dose: 160 mg. Intravenous Adjunct in balanced anaesthesia Adult: Induction: 0.3-3 mg/kg over 10-15 min. Maintenance: 0.25-0.5 mg/kg as single admin if required. Hepatic impairment: Caution; dose reduction may be necessary; monitor Child Dose: Pain <1 year: Safety and efficacy not established >1 year: 0.1-0.2 mg/kg IV/IM/SC q3-4hr PRN; individual dose not to exceed 20 mg; not to exceed 160 mg/day Renal Dose: Renal impairment: Caution; dose reduction may be necessary; monitor

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Nalbuphine Hydrochloride, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Headache • Dizziness • Sleepiness • Vomiting • Nausea • Constipation

[UNSAFE] Nalbuphine Hydrochloride may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Use Nalbuphine Hydrochloride as instructed by your doctor. Never take in greater amounts or more often than prescribed. It causes sleepiness or drowsiness. If this happens to you, do not drive or use machinery. Avoid consuming alcohol when taking the Nalbuphine Hydrochloride, as it may cause excessive sleepiness or drowsiness. Inform your doctor if you have ever been diagnosed with kidney or liver problems. Store opioid pain relievers in a safe place and out of reach of others.

Hypersensitivity. Absolute: Diarrhea associated with toxins, pseudomembranous colitis, respiratory depression (<12 beats/min) Acute asthma, bradycardia, inflammatory bowel disease, respiratory impairment

Additive CNS depressant effects may occur with other CNS depressants e.g. alcohol, anaesthetics, anxiolytics, hypnotics, TCAs and antipsychotics.

[UNSAFE] It is unsafe to consume alcohol with Nalbuphine Hydrochloride.

[SAFE IF PRESCRIBED] Nalbuphine Hydrochloride is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

[SAFE IF PRESCRIBED] Nalbuphine Hydrochloride is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CAUTION] Nalbuphine Hydrochloride should be used with caution in patients with kidney disease. Dose adjustment of Nalbuphine Hydrochloride may be needed. Please consult your doctor. [CAUTION] Nalbuphine Hydrochloride should be used with caution in patients with liver disease. Dose adjustment of Nalbuphine Hydrochloride may be needed. Please consult your doctor.

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