৳ 100.68/unit
Pack: ৳ 100.68
৳ 100.68/unit
Pack: ৳ 100.68
At a glance
Nalbuphine Hydrochloride is an opioid analgesic used for moderate to severe pain. It blocks transmission of pain signals to the brain to lower pain perception.
Indications
- Moderate to severe pain
- Pain associated with myocardial infarction
- Supplement to balanced anesthesia
- Preoperative and postoperative analgesia
- Obstetrical analgesia during labor
Pharmacology
Nalbuphine binds to opioid receptors to alter pain perception. It acts primarily as a kappa agonist and partial mu antagonist.
Dosage
Adult Dose (Parenteral):
- Moderate-severe pain: IM/IV/SC: 10-20 mg 3-6 hrly; non-opioid-tolerant patients max single dose 20 mg; max daily 160 mg
- Anesthesia supplement: Induction: 0.3-3 mg/kg over 10-15 min; Maintenance: 0.25-0.5 mg/kg
- Myocardial infarction: Slow IV 10-20 mg, repeat after 30 min if needed
Pediatric Dose (18 months-15 years): 0.2 mg/kg IV/IM, 4-6 hrly
Side effects
Common Side Effects:
- Sedation
- Sweating
- Nausea, vomiting
- Dizziness, vertigo
- Dry mouth
- Headache
- Respiratory depression
- Dyspnea and asthma
Use in pregnancy
Use in Pregnancy: Nalbuphine is safe during pregnancy (Category B); placental transfer is high and rapid. Use only if clearly needed.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Caution in patients with impaired respiratory function
- Caution in renal and hepatic impairment
- Caution in biliary tract surgery, myocardial infarction and hypotension
- Caution when driving or doing activities requiring concentration (may cause drowsiness and dizziness)
- Avoid alcohol
Overdose effects
Overdose: Sleepiness and mild dyspnea; naloxone or nalmefene as antidote; oxygen, IV fluids, vasopressors and supportive measures.
Storage conditions
Store below 30°C; protect from light; keep out of reach of children.