৳ 4/unit
Pack: ৳ 40
৳ 4/unit
Pack: ৳ 40
At a glance
Diclofenac Potassium is an NSAID used for the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, migraine, and acute pain.
Indications
- Rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
- Migraine
- Post-traumatic pain
- Post-operative pain
- Primary dysmenorrhea
- Acute gout
- Renal colic
Pharmacology
Diclofenac is a phenylacetic acid derivative and a prototypical NSAID. It reversibly inhibits cyclooxygenase (COX-1 and COX-2) enzymes, resulting in reduced synthesis of prostaglandin precursors.
Dosage
Adult (Rheumatoid Arthritis, Osteoarthritis, Ankylosing Spondylitis, Mild-to-Moderate Acute Pain): 50 mg PO q8-12hr.
Adult (Migraine): 50 mg at first sign of attack; additional 50 mg after 2 hours if needed; max 200 mg/day.
Children (>14 years): Up to 75 mg/day in divided doses.
Hepatic impairment: Dose adjustment may be needed.
Side effects
Common: GI discomfort, epigastric pain, eructation, nausea, diarrhea, headache.
Occasional: Skin rash, peripheral edema, serum transaminase abnormalities.
Rare: Peptic ulcer, haematemesis, melena, blood dyscrasia, anaphylactoid reactions.
Use in pregnancy
Pregnancy Category C. Avoid use of NSAIDs starting at 30 weeks of gestation (third trimester) due to risk of premature closure of fetal ductus arteriosus.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
History of GI ulceration; impaired cardiac, renal or hepatic function; hypertension; elderly and debilitated patients; asthma, porphyria. Monitor LFTs. May prolong bleeding time; caution in coagulation disorders or on anticoagulants.
Overdose effects
Treatment of overdose is symptomatic.
Storage conditions
Keep below 30°C temperature, away from light & moisture. Keep out of reach of children.