৳ 5/unit
Pack: ৳ 50
৳ 5/unit
Pack: ৳ 50
At a glance
Sibutramine Hydrochloride is an anti-obesity medication used for weight management in obesity. It inhibits reuptake of norepinephrine, serotonin, and dopamine to increase satiety and reduce appetite.
Indications
- Obesity
Pharmacology
Sibutramine inhibits reuptake of norepinephrine, serotonin, and dopamine at the neuronal synapse. Increased levels of these neurotransmitters promote satiety, reduce appetite, and decrease food intake, leading to weight loss.
Dosage
Adult Dose (Oral):
- Starting: 10 mg once daily (with or without food)
- Dose titration: Increase to 15 mg/day after 4 weeks if inadequate weight loss
- 5 mg dose: For patients who do not tolerate the 10 mg dose
- Maximum: 15 mg/day; doses above 15 mg/day are not recommended
Side effects
Common Side Effects:
- Dry mouth
- Anorexia
- Insomnia
- Constipation
- Headache
Use in pregnancy
Use in Pregnancy: Adequate information not available; consult your doctor.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Do not use in history of coronary artery disease, CHF, tachycardia, peripheral arterial disease, arrhythmia, or cerebrovascular disease
- Do not use in uncontrolled hypertension >145/90 mmHg
- Do not use in patients over 65 years
- Do not use with MAOIs
- Do not use in major eating disorders (anorexia nervosa or bulimia)
Overdose effects
Overdose may cause hypertension, tachycardia, and serotonin syndrome; provide symptomatic treatment.
Storage conditions
Store in a cool and dry place, protected from light; keep out of reach of children.