৳ 120.36/unit
Pack: ৳ 120.36
৳ 120.36/unit
Pack: ৳ 120.36
At a glance
Ceftriaxone is a third generation cephalosporin antibiotic used to treat bacterial infections of the brain, lungs, ear, urinary tract, skin, soft tissues, bones, joints, blood, and heart.
Indications
- Lower Respiratory Tract Infections
- Acute Bacterial Otitis Media
- Skin and Skin Structure Infections
- Urinary Tract Infections
- Gonorrhea
- Bacterial Septicemia
- Bone and Joint Infections
- Meningitis
- Prevention of Postoperative Infections
Pharmacology
Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic. It has potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. Like other cephalosporins and penicillins, Ceftriaxone kills bacteria by interfering with the synthesis of the bacterial cell wall. Ceftriaxone has a high degree of stability in the presence of beta lactamases. A remarkable feature of Ceftriaxone is its relatively long plasma elimination half-life of about 6 to 9 hours, which makes single or once-daily dosage of the drug appropriate for most patients. Ceftriaxone is not metabolized in the body. About 40-65% of a dose of Ceftriaxone is excreted unchanged in the urine; the remainder is excreted in the bile and ultimately found in the feces as unchanged drug and microbiologically inactive compound. The drug is highly protein bound (95%).
Dosage
Adult Dose:
| Infection Type | Dose | Schedule | Duration |
|---|---|---|---|
| Susceptible infections | 1-2 g/day | Single dose or divided | — |
| Severe infections | Up to 4 g/day | — | — |
| Complicated Intra-abdominal | 1-2 g/day | Single or 12 hourly | 4-7 days |
| Meningitis | 2 g | 12 hourly | 7-14 days |
| Pyelonephritis | 1-2 g | Daily | — |
| Typhoid fever | 2 g | Daily | 14 days |
| Uncomplicated Gonorrhea | 250 mg (IM) | Single dose | — |
| Pelvic Inflammatory Disease | 250 mg (IM) | Single dose | — |
Surgical Prophylaxis: 1 g IV 0.5-2 hours before procedure.
Pediatric Dose (1 month or older):
| Infection Type | Dose | Schedule |
|---|---|---|
| Pneumonia, Bronchitis, Skin, UTI, Septicemia, Bone & Joint | 50-75 mg/kg/day (max 2 g/day) | Single or 2 divided doses |
| Otitis Media | 50 mg/kg (max 1 g) | IM single dose |
| Meningitis | 100 mg/kg/day (max 4 g/day) | Single or 2 divided doses |
Renal Dose: CrCl <10 ml/min: Max 2 g/day.
Side effects
Common Side Effects:
- Abnormal liver function tests
- Diarrhea
- Rash
- Nausea
- Vomiting
- Eosinophilia
- Thrombocytopenia
- Headache
- Dizziness
Use in pregnancy
[SAFE IF PRESCRIBED] Ceftriaxone is safe to use during pregnancy. Most studies have shown low or no risk to the developing baby. Pregnancy Category B.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- [UNSAFE] Ceftriaxone may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
- Your doctor has prescribed Ceftriaxone to cure your infection and improve your symptoms. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection harder to treat.
- Discontinue Ceftriaxone and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
- During prolonged treatment the blood picture should be checked at regular intervals.
- Shadows suggesting sludge have been detected by sonograms of the gallbladder; this condition is reversible on discontinuation or completion of therapy.
Overdose effects
There is no specific antidote. Treatment of overdosage should be symptomatic.
Storage conditions
Store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children.