Pizofen 0.5

Pizotifen is a medicine used for the prevention of migraine. However, it cannot treat an acute attack and will only work to prevent migraines for as long as you continue to take the medicine. This medicine relaxes the brain, preventing migraine headache. Pizotifen may be taken with or without food, preferably at night. However, it is advisable to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Do not skip any doses and finish the full course of treatment even if you feel better. If you have missed a dose, take it as soon as you remember it. Side effects associated with the use of this medicine include dryness in mouth, increased appetite, and feeling sick. It may cause sleepiness in the beginning of your treatment, do not drive or operate machinery until you know how this medicine affects you. It may also cause weight gain, eat a healthy balanced diet, avoid snacking with high-calorie food, and exercise regularly to prevent it. It is important to consult your doctor if you develop a skin rash, muscle aches, tremors, or difficulty moving after taking this medicine. You should avoid alcohol consumption while taking this medicine as it may result in increased sedation. If you are taking this medicine for a long-term, regular monitoring of liver function and vision is recommended. Migraine headaches are thought to result from the dilatation of blood vessels in the head. Pizotifen is a serotonin antagonist. It works by maintaining the level of serotonin (chemical messenger) in the brain and also prevents loss of tone and dilation of blood vessels, thus preventing the migraine headache.

• Migraine

Pizotifen is a sedating antihistamine with strong serotonin antagonist and weak antimuscarinic properties. It also antagonises the action of tryptamine.

Adult Dose: Oral Prophylaxis of migraine; Prophylaxis of cluster headache Adult: Initially, 0.5 mg, increase gradually as necessary. Maintenance: 1.5 mg daily as a single dose at night or in 3 divided doses. Max: 4.5 mg daily (max ?3 mg/dose). Hepatic impairment: Dose adjustment may be needed. Child Dose: Oral Prophylaxis of migraine; Prophylaxis of cluster headache Child: >2 yr Initially, 0.5 mg. May increase gradually up to 1.5 mg daily in divided doses (max 1 mg/dose). Renal Dose: Renal impairment: Dose adjustment may be needed.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pizotifen may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Pizotifen, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Sleepiness • Dryness in mouth • Increased appetite • Dizziness • Drowsiness • Feeling sick

[UNSAFE] Pizotifen may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. You have been prescribed Pizotifen for the prevention of migraine headaches. Do not take it to treat an acute attack of migraine. Some tips that may help avoid a migraine attack: It should be taken at night-time before going to bed. It may cause sleepiness. Don't drive or do anything that requires mental focus until you know how Pizotifen affects you. You may experience weight gain while on treatment. Monitoring of body weight is required on a regular basis. Notify your doctor if you develop skin rash, muscle aches, tremors, difficulty moving, or abnormal uncontrolled movement.

Premature infants or neonates. Postural giddiness.

Enhances sedative effects of CNS depressants. Additive antimuscarinic action with other antimuscarinic drugs. May mask warning signs of damage caused by ototoxic drugs eg, aminoglycosides.

[CAUTION] Caution is advised when consuming alcohol with Pizotifen. Please consult your doctor.

[CONSULT YOUR DOCTOR] Information regarding the use of Pizotifen during pregnancy is not available. Please consult your doctor.

[CONSULT YOUR DOCTOR] Information regarding the use of Pizotifen during breastfeeding is not available. Please consult your doctor.

[CAUTION] Pizotifen should be used with caution in patients with kidney disease. Dose adjustment of Pizotifen may be needed. Please consult your doctor. [CAUTION] Pizotifen should be used with caution in patients with liver disease. Dose adjustment of Pizotifen may be needed. Please consult your doctor.

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