osudhkosh
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Company•ACI Limited

Posac 100

Rx
Generic: Posaconazole

৳ 200/unit

Pack: ৳ 2,000

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At a glance

Posaconazole is an antifungal used for treatment of invasive aspergillosis, fusariosis, chromoblastomycosis, mycetoma, and coccidioidomycosis in patients aged 13 years and above, and for prophylaxis of invasive fungal infections.

Indications
  • Invasive aspergillosis (refractory/intolerant to Amphotericin B or Itraconazole)
  • Fusariosis (refractory/intolerant to Amphotericin B)
  • Chromoblastomycosis and mycetoma (refractory/intolerant to Itraconazole)
  • Coccidioidomycosis (refractory/intolerant to Amphotericin B, Itraconazole, or Fluconazole)
  • Prophylaxis of invasive fungal infections in AML/MDS patients with prolonged neutropenia
  • HSCT recipients on high-dose immunosuppressive therapy for GVHD
Pharmacology

Posaconazole blocks ergosterol synthesis by inhibiting the cytochrome P-450 dependent enzyme Lanosterol 14-α-demethylase. This causes accumulation of methylated sterol precursors and depletion of ergosterol, weakening the fungal cell membrane structure and function.

Dosage

Adult Dose (Oral/IV):

  • Loading dose: 300 mg (3 tablets) twice daily on Day 1
  • Maintenance dose: 300 mg (3 tablets) once daily from Day 2
  • Oral suspension (prophylaxis): 200 mg three times daily
  • Oral suspension (oropharyngeal candidiasis): 100 mg twice daily (Day 1), then 100 mg once daily for 13 days
  • Itraconazole/fluconazole-refractory: 400 mg twice daily

Pediatric Dose (≥13 years): Same as adult

Side effects

Common Side Effects:

  • Diarrhea
  • Nausea
  • Fever
  • Vomiting
  • Headache
  • Coughing
  • Hypokalemia
Use in pregnancy

Use in Pregnancy: May be unsafe during pregnancy; animal studies have shown harmful effects; use only if clearly needed.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • May affect driving ability (dizziness, drowsiness, blurred vision)
  • Monitor liver function tests at the start and during therapy
  • Caution in pregnancy and lactation
  • Avoid IV administration in moderate-severe renal impairment (eGFR <50 mL/min)
Overdose effects

No overdose information available; consult your doctor if taken in excess.

Storage conditions

Store below 25°C; keep out of reach of children.

Posaconazole — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.