Xpos 100 DR100mg

Posaconazole belongs to a group of medicines called antifungals. It works by stopping the growth of fungus and is used to treat fungal infection. It kills fungi by destroying the fungal cell membrane. Posaconazole is an injectable drug and given as an injection by a healthcare professional. Do not self administered the injection. Your doctor or nurse will teach you the correct way of injecting it. To get the most benefit, take this medicine at evenly spaced times and continue using it until your prescription is finished, even if your symptoms disappear after a few days. If you stop treatment too early, the infection may return and if you miss doses you can increase your risk of infections that are resistant to further treatment. The most common side effects of this medicine include headache, diarrhea, feeling sick (nausea) and low potassium level. These are not usually serious, but you should call your doctor if you think you might have a severe allergic reaction and sign of liver problems such as yellowing of eyes, dark urine and stomach problems. Get emergency help if this happens. Do not take it if you are pregnant or could become pregnant unless your doctor has told you to. Talk to your doctor before taking it if you have ever had heart failure, kidney problems or liver problems such as yellow skin (jaundice). This medicine may not be suitable for you. If your course of treatment is for more than a month, your doctor may want to check your liver, and potassium level by testing your blood. This medicine may make you dizzy or have blurred vision so do not drive or operate machines until it is safe. Posaconazole is an antifungal medication. It kills fungi by destroying the fungal cell membrane. This treats your infection.

• Severe fungal infections

Blocks the synthesis of ergosterol, a key component of the fungal cell membrane, through the inhibition of the enzyme lanosterol 14-α-demethylase and accumulation of methylated sterol precursors. Posaconazole has activity against Candida spp., Aspergillus spp., Coccidioides immitis, Fonsecaea pedrosoi, and some species of Fusarium and zygomycetes.

Adult Dose: Oral Prophylaxis of invasive fungal infections Adult: As delayed-release tab: 300 mg bid on the 1st day, then 300 mg once daily thereafter. As oral susp: 200 mg tid. Treatment duration is based on recovery from neutropenia or immunosuppression. Oral Oropharyngeal candidiasis Adult: As oral susp: 100 mg bid on the 1st day, then 100 mg once daily, for 13 days. Oropharyngeal candidiasis refractory to itraconazole and/or fluconazole Adult: As oral susp: 400 mg bid. Treatment duration is based on patient's underlying disease and clinical response. Intravenous Prophylaxis of invasive fungal infections Adult: 300 mg bid on the 1st day, then 300 mg once daily thereafter. Treatment duration is based on recovery from neutropenia or immunosuppression. Child Dose: Invasive Aspergillus & Candida Infections Indicated for prophylaxis of invasive Aspergillus and Candida infections in patients who are at high risk of developing these infections due to being severely immunocompromised (eg, hematopoietic stem cell transplant recipients with GVHD, hematologic malignancies with prolonged neutropenia from chemotherapy) 13 years Oral suspension: 200 mg (5 mL) TID Tablet: 300 mg PO BID on Day 1, then 300 mg PO qDay Duration of therapy is based on recovery from neutropenia or immunosuppression Oropharyngeal Candidiasis Oral suspension is indicated for oropharyngeal candidiasis 13 years Oral suspension: 100 mg (2.5 mL) PO BID on Day 1, then 100 mg PO qDay for 13 days Refractory to itraconazole and/or fluconazole: 400 mg (10 mL) PO BID; duration based on severity of underlying disease and clinical response Renal Dose: Moderate-to-severe renal impairment (IV) eGFR <50 mL/min: Avoid IV administration unless benefit/risk assessment justifies use Accumulation of the IV vehicle, SBECD, is expected to occur Serum creatinine levels should be closely monitored; if increases occur, consideration should be given to changing to oral posaconazole therapy Severe renal impairment (tablets or oral suspension) Variability of systemic exposure with tablets or oral suspension observed Monitored closely for breakthrough fungal infections

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Common: • Headache • Vomiting • Cough • Nausea

[UNSAFE] Posaconazole may cause side effects which could affect your ability to drive. As you may feel dizzy, sleepy, or have blurred vision while taking Posaconazole, which may affect your ability to drive. Your doctor has prescribed Posaconazole to cure your infection and improve symptoms. Do not skip any doses and finish the full course of treatment even if you feel better. It is given as an injection under the supervision of a healthcare professional. Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Hypersensitivity. Co-admin w/ sirolimus, ergot alkaloids (e.g. ergotamine, dihydroergotamine), CYP3A4 substrates (terfenadine, astemizole, cisapride, pimozide, halofantrine, or quinidine), and HMG-CoA reductase inhibitors (e.g. simvastatin, lovastatin, atorvastatin).

Decreased plasma concentrations w/ efavirenz, fosamprenavir, cimetidine, esomeprazole, metoclopramide, phenytoin and rifabutin. May increase plasma concentration of ritonavir and atazanavir. May increase risk of neurotoxicity w/ vinca alkaloids (e.g. vincristine, vinblastine). May increase plasma concentrations of tacrolimus, ciclosporin, midazolam, Ca channel blockers (e.g. verapamil, diltiazem, nifedipine, nicardipine, felodipine) and digoxin.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Posaconazole. Please consult your doctor.

[CONSULT YOUR DOCTOR] Posaconazole may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Posaconazole is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[CAUTION] Posaconazole should be used with caution in patients with kidney disease. Dose adjustment of Posaconazole may be needed. Please consult your doctor. Regular monitoring of kidney function tests is advised while taking this medicine. Use of Posaconazole is not recommended in patients with moderate to severe kidney disease. [SAFE IF PRESCRIBED] Posaconazole is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Posaconazole may not be needed in these patients. Please consult your doctor.

I have been experiencing fungal infections, I develop rings and rashes and they all itch like anything. I formed scars because of it. I have been taking Grisovin FP 250 mg however as long I take it I am relieved, even if I miss it for 1 day I start getting fungus back. On top of that Grisovin FP is difficult to find now, please suggest. You are having fungal infections severe, you need to change the medicine by skin specialistCan b prescribed under supervisionMeanwhile apply onabet cream twice a day Medicine for fungal infections. There is hundred type of fungal infectionFrom which you sufferBetter visit clinic for proper examination Fungal infections on body & face Cap. Itraconazole (Itrasys/ Canditral) 100mg twice daily for 2 weeks.Sertacide Cream for application twice daily for 1 month.Send pictures for better diagnosis and treatment How to treat fungal infections Stop all other applications. Cap. Itraconazole (Itrasys/ Canditral) 100mg twice daily for 2 weeks. Sertacide Cream for application twice daily for 1 month.Tab. Fexova 180 mg (if required in case of itching) Test ? Blood sugar ( Fasting & PP) The treatment has to be complete otherwise it will be recur. Fungal infections on thigh ittching Onabet cream twice a day meanwhile visit skin specialist for proper examination and treatment I am regularly using the cream cosmelite But now due to a fungal infection i have to use a antifungal cream fungicros So So i want to know whether i can apply the cream cosmelite after fungicros Pls tell me which part of body have fungal infections What kind of antibiotics should be taken for groin fungal infection along with the micanazole cream? Antibiotic is not required for fungal infection, antifungals like itraconazole, terbinafine, etc are used for fungal infections Fungal infections on face and body Cap. Itraconazole (Itrasys/ Canditral) 100mg twice daily for 2 weeks. Sertacide Cream for application twice daily for 1 month.Tab. Fexova 180 mg (if required in case of itching)