৳ 11.74/unit
Pack: ৳ 117.40
৳ 11.74/unit
Pack: ৳ 117.40
At a glance
Isoniazid + Pyrazinamide + Rifampicin combination is used in the treatment of tuberculosis (TB).
Indications
- Tuberculosis (TB)
Pharmacology
Isoniazid prevents TB bacteria from forming their own protective covering. Rifampicin inactivates bacterial enzyme (RNA-polymerase) which is required by bacteria to make essential proteins and to reproduce. Pyrazinamide slows the growth of these bacteria. Together, they kill the bacteria and eradicate the infection.
Dosage
Adult Dose (Oral):
- Take as part of TB treatment regimen as prescribed
- Take on empty stomach
Child Dose: Dose determined by physician based on weight
Side effects
Common Side Effects:
- Nausea
- Vomiting
- Fever
- Rash
- Dark colored urine
- Sweating
- Increased salivation
- Peripheral neuropathy (tingling and numbness of feet and hand)
- Increased liver enzymes
- Jaundice
- Increased uric acid level in blood
- Gout
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies have shown harmful effects; doctor will weigh benefits and risks.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Isoniazid + Pyrazinamide + Rifampicin may affect your ability to drive (dizziness, vision problems)
- Regular monitoring of liver function tests advised
- Avoid alcohol (may cause disulfiram reaction)
- Caution in kidney and liver disease
- Caution in pregnancy and lactation
Overdose effects
Overdose: Nausea, vomiting, abdominal pain, dizziness, confusion, liver toxicity; seek emergency medical attention; gastric lavage and activated charcoal; symptomatic treatment.
Storage conditions
Keep below 30°C temperature, away from light & moisture; keep out of reach of children.