৳ 8/unit
Pack: ৳ 80
৳ 8/unit
Pack: ৳ 80
At a glance
Ritodrine Hydrochloride is a β2-adrenergic agonist used for the treatment of uncomplicated premature labor. It relaxes the uterus by stimulating β2-adrenergic receptors of the uterine muscle, decreasing the intensity and frequency of contractions.
Indications
- Uncomplicated premature labor
Pharmacology
Ritodrine stimulates β2-adrenergic receptors on uterine muscle, increasing cAMP and sequestering intracellular calcium, which decreases myometrial contractility and relaxes the uterus. It reduces the intensity and frequency of contractions, delaying premature delivery.
Dosage
Adult Dose (IV):
- Initial: 50 mcg/min; increase by 50 mcg/min every 10 minutes until contractions stop or maternal heart rate reaches 140/min; usual rate: 150-350 mcg/min; max 350 mcg/min
Adult Dose (IM):
- 10 mg every 3-8 hours; continued for 12-48 hours after contractions have ceased
Adult Dose (Oral):
- 10 mg approximately 30 minutes before termination of IV therapy; repeat every 2 hours for 24 hours; then 10-20 mg every 4-6 hours; max 120 mg/day
Side effects
Common Side Effects:
- Breathlessness
- Chest discomfort
- Increased blood glucose
- Increased heart rate
- Palpitations
- Tremor
- Nausea
- Vomiting
- Flushing
- Sweating
- Hypokalemia
Use in pregnancy
Use in Pregnancy: Pregnancy Category B; do not use before 20 weeks; studies from 20 weeks onwards have not shown increased risk of fetal abnormalities; use only when clearly indicated.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Avoid over-hydration
- Monitor blood pressure and pulse rate regularly
- Caution in cardiac disease, hypertension, diabetes, hyperthyroidism
- Inform doctor if contractions begin again or water breaks
Overdose effects
Overdose: Tachycardia (maternal and fetal), palpitations, cardiac arrhythmia, hypotension, nervousness, tremor, nausea, vomiting; treatment: gastric lavage or induction of emesis, activated charcoal; for parenteral overdose, discontinue ritodrine, β-blocking agent may be used as an antidote.
Storage conditions
Keep away from reach of children; store in cool and dry place, protected from light.