৳ 20/unit
Pack: ৳ 200
৳ 20/unit
Pack: ৳ 200
At a glance
Pimavanserin is used for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis. It is a selective serotonin inverse agonist and antagonist that targets 5-HT2A receptors believed to play an important role in psychosis.
Indications
- Hallucinations and delusions associated with Parkinson's disease psychosis
Pharmacology
Pimavanserin is a selective serotonin inverse agonist and antagonist that targets 5-HT2A receptors. It works through inverse agonist and antagonist activity at these receptors, helping to reduce hallucinations and delusions associated with Parkinson's disease psychosis.
Dosage
Adult Dose (Oral):
- Parkinson disease psychosis: 34 mg once daily (two 17 mg tablets), without titration
- Hepatic impairment: No dosage adjustment recommended (not recommended)
- With strong CYP3A4 inhibitors: Reduce dose to 17 mg once daily
Side effects
Side Effects (1-10%):
- Nausea (7%)
- Peripheral edema (7%)
- Confusional state (6%)
- Hallucinations (5%)
- Constipation (4%)
- Gait disturbance (2%)
Use in pregnancy
Use in Pregnancy: No data for use in pregnant women to assess drug-associated risk; animal studies showed no adverse effects during organogenesis at up to 10-12 times the 34 mg/day MRHD.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Antipsychotic drugs increase all-cause risk of death in elderly patients with dementia-related psychosis
- QT interval prolongation; avoid in known QT prolongation, with Class 1A/3 antiarrhythmics, certain antipsychotics, certain antibiotics
- Avoid in history of cardiac arrhythmias, symptomatic bradycardia, hypokalemia, hypomagnesemia, congenital QT prolongation
- Strong CYP3A4 inhibitors/inducers affect systemic exposure
Overdose effects
No overdose information available; consult your doctor if taken in excess.
Storage conditions
Store below 30°C, away from light and moisture; keep out of reach of children.