৳ 20/unit
Pack: ৳ 200
৳ 20/unit
Pack: ৳ 200
At a glance
Solifenacin Succinate is a muscarinic receptor antagonist used for the treatment of overactive bladder (OAB) symptoms such as frequent urination, urgent need to urinate, and inability to control urination.
Indications
- Overactive bladder (OAB) – urgency, increased urinary frequency, urge incontinence
Pharmacology
Solifenacin blocks M2 and M3 muscarinic receptors in the bladder, relaxing the detrusor muscle, increasing bladder capacity, and reducing urinary urgency and frequency.
Dosage
Adult Dose (Oral):
- Starting: 5 mg once daily
- If needed and tolerated: 10 mg once daily
- With CYP3A4 inhibitors (ketoconazole, ritonavir): Max 5 mg/day
- Severe renal impairment (CrCl <30): Max 5 mg/day
- Moderate hepatic impairment (Child-Pugh B): Max 5 mg/day
Side effects
Common Side Effects:
- Dry mouth (very common: 11-22%)
- Constipation, nausea, dyspepsia
- Abdominal pain, blurred vision
- Urinary tract infection
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies show harmful effects; use only if clearly needed; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Do not use in uncontrolled narrow-angle glaucoma, urinary retention, gastric retention
- Caution in clinically significant bladder outflow obstruction, GI obstructive disorders
- Severe renal or moderate hepatic impairment: Do not exceed 5 mg
- May affect driving ability (blurred vision, drowsiness)
Overdose effects
Overdose may cause severe anticholinergic effects; highest dose 280 mg/5 hours caused mental status changes; activated charcoal; gastric lavage (within 1 hour); physostigmine, benzodiazepines, beta-blockers, catheterization; caution in QT-prolongation risk.
Storage conditions
Store in a cool and dry place, protected from light; keep out of reach of children.