Soria-D
0.05%+0.00%/100gmRx৳ 380/unit
Pack: ৳ 380
৳ 380/unit
Pack: ৳ 380
At a glance
Betamethasone 0.05% + Calcipotriol 0.005% topical is a combination preparation used for the treatment of plaque-type psoriasis vulgaris and plaque psoriasis of the scalp and body. It provides relief from redness, itching and swelling and decreases the overproduction of skin cells.
Indications
- Plaque-type psoriasis vulgaris
- Plaque psoriasis of the scalp
- Plaque psoriasis of the body
Pharmacology
Betamethasone Dipropionate is a potent topically-active corticosteroid producing prompt, marked and prolonged anti-inflammatory, antipruritic, vasoconstrictive and immunosuppressive properties. These effects can be enhanced under occlusive conditions due to increased penetration of stratum corneum (by approximately a factor of 10).
Calcipotriol is a non-steroidal antipsoriatic agent, derived from vitamin D. It exhibits a vitamin D-like effect by competing for the 1,25(OH)2D3 receptor. Calcipotriol induces differentiation and suppresses proliferation of keratinocytes, thus reversing the abnormal keratinocyte changes in psoriasis.
Dosage
Ointment: Apply topically to the affected area once daily. Maximum daily dose: 15 g. Maximum weekly dose: 100 g. Treated area should not exceed 30% of body surface. Treatment should be limited to four-week periods with Calcipotriol used alone for one month between periods as needed.
Suspension (Spray): Apply once daily to the affected areas and gently rub in. Treatment may be continued for up to 8 weeks. Maximum weekly dose: 100 g. Shake before use.
Children: Not recommended for use in children and adolescents below 18 years of age.
Side effects
- Folliculitis
- Burning sensation
- Itching
- Rash
- Skin atrophy
- Striae
- Hypopigmentation
- Allergic contact dermatitis
Use in pregnancy
[CONSULT YOUR DOCTOR] There are no adequate well-controlled studies in pregnant women. Use only if potential benefit justifies the potential risk to the fetus.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- If hypercalcemia or hypercalciuria occurs, discontinue until calcium metabolism normalizes
- Topical corticosteroids may cause HPA axis suppression, Cushing's syndrome, and unmask latent diabetes
- Not recommended for use on face, axillae, groin or where atrophy is present
- Children may be more susceptible to systemic toxicity from topical corticosteroids
- Caution during pregnancy and lactation
Overdose effects
Overuse may cause HPA axis suppression and calcium metabolism disorders. Consult a doctor if symptoms occur.
Storage conditions
Store below 25°C, in a cool and dry place, protected from light. Do not refrigerate. Keep out of reach of children.