Taziaid

• Lower Respiratory Tract Infections (including pneumonia)
• Skin and Skin Structure Infections
• Urinary Tract Infections (complicated and uncomplicated)
• Bacterial Septicemia
• Bone and Joint Infections
• Gynecologic Infections (endometritis)
• Intraabdominal Infections (peritonitis)
• Central Nervous System Infections (meningitis)

Ceftazidime is a semisynthetic, broad-spectrum, beta-lactam antibiotic for parenteral administration. Ceftazidime is bactericidal in action exerting its effect by inhibition of enzymes responsible for cell-wall synthesis. A wide range of gram-negative organisms is susceptible to ceftazidime in vitro, including strains resistant to gentamicin and other aminoglycosides. In addition, ceftazidime has been shown to be active against gram-positive organisms. It is highly stable to most clinically important beta-lactamases, plasmid or chromosomal, which are produced by both gram-negative and gram-positive organisms and, consequently, is active against many strains resistant to ampicillin and other cephalosporins.

Adult Dose:

Pediatric Dose (>2 months): 30-100 mg/kg/day (2-3 divided doses); severe infections up to 150 mg/kg/day (max 6 g/day) in 3 divided doses.

Neonates & up to 2 months: 25-60 mg/kg/day (2 divided doses).

Elderly (>80 years): Max 3 g/day.

Renal Dose:

Loading dose: 1 g; Peritoneal dialysis: 500 mg every 24 hours after loading dose; Hemodialysis: 0.5-1 g after each dialysis.

Hepatic impairment: No dose adjustment required.

Common Side Effects:

• Rash
• Allergic reaction
• Injection site reaction
• Diarrhea
• Nausea
• Vomiting
• Abdominal pain
• Headache
• Dizziness

[SAFE IF PRESCRIBED] Ceftazidime is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies. Pregnancy Category B. This drug should be used during pregnancy only if clearly needed.

• [UNSAFE] Ceftazidime may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
• Your doctor has prescribed Ceftazidime to cure your infection and improve your symptoms. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection harder to treat.
• Discontinue Ceftazidime and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
• Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
• Avoid consuming alcohol while taking Ceftazidime as it may cause increased side effects.
• Ceftazidime should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis.

Ceftazidime overdosage has occurred in patients with renal failure. Reactions have included seizure activity, encephalopathy, asterixis, neuromuscular excitability, and coma. Patients who receive an acute overdosage should be carefully observed and given supportive treatment.

Store below 25°C, protected from light and moisture. Reconstituted solutions are stable for up to 24 h if stored between 2°-8°C.