Tobidex
0.1%+0.3%Rx৳ 145/unit
Pack: ৳ 145
৳ 145/unit
Pack: ৳ 145
At a glance
Gramicidin + Neomycin + Polymyxin B is an ophthalmic solution used for the topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria.
Indications
- Conjunctivitis
- Keratitis
- Keratoconjunctivitis
- Blepharitis
- Blepharoconjunctivitis
Pharmacology
Neomycin is an aminoglycoside antibiotic which inhibits protein synthesis by binding with ribosomal RNA and causing misreading of the bacterial genetic code. Polymyxin B increases the permeability of the bacterial cell membrane by interacting with the phospholipid components of the membrane. Gramicidin increases the permeability of the bacterial cell membrane to inorganic cations by forming a network of channels through the normal lipid bilayer of the membrane.
Dosage
Adult: Instill 1-2 drops into the affected eye every 4 hours for 7-10 days. In severe infections, may increase to 2 drops every hour.
Side effects
Common: Allergic reactions (itching, swelling, conjunctival erythema).
Rare: Anaphylaxis, local irritation.
Use in pregnancy
Pregnancy Category C. Adequate animal reproductive studies have not been conducted. Should be given to a pregnant woman only if clearly needed.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Prolonged use may result in overgrowth of nonsusceptible organisms including fungi. If superinfection occurs, appropriate measures should be initiated. Bacterial resistance may develop. If purulent discharge, inflammation or pain becomes aggravated, discontinue use and consult a physician.
Overdose effects
No adequate information on overdose is available.
Storage conditions
Store in a cool and dry place.