Triokit
30mg+500mg+1gmRx৳ 13.84/unit
Pack: ৳ 55.36
৳ 13.84/unit
Pack: ৳ 55.36
At a glance
Amoxicillin + Clarithromycin + Lansoprazole Kit is a combination medicine used in the treatment of peptic ulcer disease by relieving symptoms such as heartburn, indigestion, stomach pain, and irritation. It works by killing the ulcer-causing bacteria H. pylori.
Indications
- Peptic ulcer disease
- H. pylori infection
- Duodenal ulcer (active or 1-year history)
Pharmacology
Lansoprazole: Proton pump inhibitor that binds to H+/K+-ATPase (proton pump) in gastric parietal cells, blocking acid secretion. Amoxicillin: Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, inhibiting the final transpeptidation step of peptidoglycan synthesis, resulting in bacterial lysis. Clarithromycin: Inhibits protein synthesis by binding to the 50S ribosomal subunit, causing antibacterial activity.
Dosage
Adult Dosage:
- Amoxicillin: 500 mg + Clarithromycin: 250 mg + Lansoprazole: 30 mg
- Twice daily (every 12 hours) for 10-14 days
- Dosage and duration as per physician's advice
Special Precautions:
- Contraindicated in severe penicillin hypersensitivity
- Clarithromycin contraindicated in QT prolongation or ventricular arrhythmia history
- Clarithromycin contraindicated in cholestatic jaundice/hepatic dysfunction history
- Not recommended in patients with CrCl <30 mL/min
Renal Dose: Dose adjustment may be needed in severe renal impairment.
Side effects
- Nausea
- Diarrhea
- Stomach pain
- Flatulence
- Indigestion
- Tiredness
- Dizziness
- Headache
- Skin rash
- Metallic taste
- Dryness in mouth
Use in pregnancy
[CONSULT YOUR DOCTOR] Amoxicillin + Clarithromycin + Lansoprazole Kit may be unsafe to use during pregnancy. Animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and risks before prescribing.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Important Precautions:
- Inform your doctor if allergic to penicillin or penicillin-type medicines
- Complete the full course - do not stop even if you feel better
- Stop and inform your doctor immediately if you develop allergic reactions (rash, swelling of face/throat/tongue, breathing difficulties)
- Avoid driving or activities requiring mental focus
- Avoid alcohol consumption (may cause Disulfiram reaction)
- Consult doctor during pregnancy
Overdose effects
Overdose may cause nausea, vomiting, diarrhea, and electrolyte imbalance. Consult your doctor if symptoms occur.
Storage conditions
Store below 30°C, away from light and moisture. Keep out of reach of children.