৳ 5,820/unit
Pack: ৳ 5,820
৳ 5,820/unit
Pack: ৳ 5,820
At a glance
Tigecycline is a glycylcycline antibiotic used for complicated skin and skin structure infections, complicated intra-abdominal infections, and community-acquired bacterial pneumonia. It inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.
Indications
- Complicated skin and skin structure infections
- Complicated intra-abdominal infections
- Community-acquired bacterial pneumonia
Pharmacology
Tigecycline binds to the 30S ribosomal subunit, blocking amino-acyl tRNA entry into the A site, inhibiting protein synthesis and peptide chain elongation. It is not affected by tetracycline resistance mechanisms and is generally bacteriostatic.
Dosage
Adult Dose (IV):
- Loading dose: 100 mg
- Maintenance: 50 mg every 12 hours
- IV infusion over 30-60 minutes
- Treatment duration: Complicated skin/IAA infections: 5-14 days; CAP: 7-14 days
Hepatic Impairment:
- Mild-moderate: No dose adjustment needed
- Severe: 100 mg single dose, then 25 mg every 12 hours
Side effects
Common Side Effects:
- Nausea, vomiting (first 1-2 days)
- Headache
- Increased liver enzymes
- Abdominal pain, diarrhea
Less Common:
- Injection site inflammation and pain
- Allergic reactions, chills
- Thrombophlebitis, bradycardia, tachycardia
- Hypoglycemia, hyponatremia
Use in pregnancy
Use in Pregnancy: Unsafe; evidence of fetal risk; use only in life-threatening situations; consult your doctor.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Caution in hypersensitivity to tetracycline-class antibiotics
- Do not use in hospital-acquired pneumonia and ventilator-associated pneumonia
- Do not use during tooth development
- May affect driving ability (dizziness)
Overdose effects
Single IV dose of 300 mg increased nausea and vomiting; no specific antidote; provide symptomatic treatment.
Storage conditions
Before reconstitution: Store at 2-8°C in a refrigerator; do not freeze; after reconstitution: store at room temperature for up to 24 hours or at 2-8°C for up to 48 hours.