Velvin Injection10mg/vial

Vinblastine is an anti-cancer medication used in the treatment of breast cancer, kidney cancer, Hodgkin’s disease, and Non-Hodgkin's lymphoma. Vinblastine is given as an injection into the vein under the supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include nausea, vomiting, diarrhea, and decreased appetite. This medicine may reduce the number of blood cells (white blood cells) in your blood, thereby, increasing the susceptibility to infections and fever. In some cases, it may also cause kidney disease related to uric acid level. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. You should take precautions while taking this medication as it may cause inflammation of mouth and lips and neurological toxicity. Vinblastine blocks replication of genetic material (DNA) in the cancer cells. Thus it stops the growth and multiplication of cancer cells.

• Breast cancer • Kidney cancer • Hodgkin’s disease • Non-Hodgkin's lymphoma

Vinblastine is M phase specific. It binds to microtubular proteins and arrests mitosis at the metaphase by disrupting mitotic spindle formation. It blocks glutamic acid utilization, thus inhibiting purine synthesis, the citric acid cycle, and the formation of urea. It may also interfere with nucleic acid and protein synthesis.

Adult Dose: Intravenous Cancers Testicular CA, Squamous cell CA of head & neck, Hodgkin's Dz, Kaposi's sarcoma; histiocytic lymphoma, mycosis fungoides, & Letterer-Siwe disease (histiocytosis X) General Dosing Ranges 3.7-18 mg/sq.meter/day IV q7-10d 1st dose 3.7 mg/sq.meter/day IV Incr by 1.85 mg/sq.meter qweek until WBC equal 3000/cu.mm NMT 18.5 mg/sq.meter Hepatic impairment Decrease dose by half if bilirubin >3 mg/dL [>51 umol/L] Child Dose: Intravenous Cancers Testicular CA, Squamous cell carcinoma CA of head & neck, Hodgkin's Dz, Kaposi's sarcoma; histiocytic lymphoma, mycosis fungoides, & Letterer-Siwe disease (histiocytosis X) General dosing ranges 2.5- 12.5 mg/sq meter IV q7-10d 1st dose 2.5 mg/sq.meter IV Incr by 1.25 mg/sq.meter qWeek until WBC = 3000/cu.mm No more than 12.5 mg/sq.meter

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Common: • Nausea • Vomiting • Decreased appetite • Decreased white blood cell count • Diarrhea

[UNSAFE] Vinblastine may cause side effects which could affect your ability to drive. In males vinblastine may cause aspermia (lack of semen causing infertility); in females vinblastine may cause amenorrhea (absence of menstruation), which may recover after some duration. Take precautions while taking vinblastine as it may cause inflammation of mouth and lips (stomatitis) and neurological toxicity. Avoid even accidental contamination of eyes with vinblastine, as it may cause severe irritation. Vinblastine may cause acute kidney disease (nephropathy) related to uric acid level. Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Severe bone marrow suppression; presence of bacterial infection; maglignant cell infiltration of bone marrow; Inj into extremity with poor circulation; porphyria; granulocytopenia. Elderly with cachexia or extreme skin ulcerations. Pregnancy; lactation. Intrathecal use may result in death.

Possible increase in vinblastine levels with aprepitant. Reduced vinblastine metabolism with miconazole. Variable interactions with phenytoin, monitor serum phenytoin levels. Reduced immune response with vaccines. Additive myelotoxicity with zidovudine. Concurrent admin of vinblastine with CYP3A inhibitors may cause an earlier onset and/or an increased severity of side effects. Potentially Fatal: Increased toxicity of vinblastine with erythromycin. Increased neurotoxicity and myelotoxicity with azole antifungals e.g. itraconazole and posaconazole. Increased risk of severe neutropenia with ritonavir. Increased risk of acute pulmonary toxicity with mitomycin. Increased toxicity when ganciclovir is given with, immediately before or after vinblastine.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Vinblastine. Please consult your doctor.

[CONSULT YOUR DOCTOR] Vinblastine is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[UNSAFE] Vinblastine is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

[SAFE IF PRESCRIBED] Vinblastine is safe to use in patients with kidney disease. No dose adjustment of Vinblastine is recommended. However, talk to your doctor if you have any underlying kidney disease. [CAUTION] Vinblastine should be used with caution in patients with liver disease. Dose adjustment of Vinblastine may be needed. Please consult your doctor. Use of Vinblastine may not be advised in patients with severe liver disease.

I have non hodgking's lymphoma. What type of treament i need? And it this cancer curable? If CD 20+ TAKE R-CHOP TREATMENT If any symtom of brest cancer if have whats the cure First is confirmation of breast cancerChance of cure depends on stage of cancer Metastatic kidney cancer stage 4 Thanks for reaching out to meHe has progressive disease on sorafenib Symptoms of lymphoma And blood cancer Symptoms could be like fever, weight loss, anorexia, lymphadenopathy. BREAST CANCER , PET REPORT SAYS INFECTION IN SKELETON. Metastatic breast cancer, send me previous treatment details I am PATIENT have pain in my breastes and feel very weight before one week of my menstrual perieds date Is it any symptoms of breast cancer ? Need your advice And also having back pain during menstrual dates please give your valubel advice No it's not a symptom of breast cancer. Doctor, I have a small red coloured lump on my Right side breast beneath Nipple. I'm scared it would be the symptom for Breast Cancer, as I googled and got shocked it might be initial stage for Breast Cancer and I'm unmarried still. Please Advice. It may be non cancerous She has breast cancer at 4 sta Dear PATIENT 4 Breast Cancer means that the cancer has spread to other parts of the body. The management of such cancers depends on the site where the cancer has spread and on the receptor status of the breast cancer. If you can share the details with me, I will be happy to let you know the potential management