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Vinblastin

10mg/vialRx
Generic: Vinblastine

৳ 720/unit

Pack: ৳ 720

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At a glance

Vinblastine is an anti-cancer medication used in the treatment of breast cancer, kidney cancer, Hodgkin's disease, and Non-Hodgkin's lymphoma.

Indications
  • Breast cancer
  • Kidney cancer
  • Hodgkin's disease
  • Non-Hodgkin's lymphoma
  • Testicular cancer
  • Kaposi's sarcoma
Pharmacology

Vinblastine binds to or crystallises critical microtubular proteins of the mitotic spindle, thus preventing their proper polymerisation and causing metaphase arrest. In high concentrations, Vinblastine also exerts complex effects on nucleic acid and protein synthesis.

Dosage

Adult Dose (IV):

  • General Dosing Ranges: 3.7-18 mg/m²/day IV every 7-10 days
  • First dose: 3.7 mg/m²/day IV; increase by 1.85 mg/m² weekly until WBC equals 3000/cu.mm; max 18.5 mg/m²
  • Testicular tumors: 0.2 mg/kg on each of two consecutive days every three weeks
  • Hepatic impairment: Decrease dose by half if bilirubin >3 mg/dL

Child Dose (IV):

  • General dosing ranges: 2.5-12.5 mg/m² IV every 7-10 days
  • First dose: 2.5 mg/m² IV; increase by 1.25 mg/m² weekly until WBC equals 3000/cu.mm; no more than 12.5 mg/m²
Side effects

Common Side Effects:

  • Nausea
  • Vomiting
  • Decreased appetite
  • Decreased white blood cell count
  • Diarrhea
  • Alopecia
  • Constipation
  • Stomatitis
  • Neurotoxicity
Use in pregnancy

Use in Pregnancy: Unsafe; definite evidence of risk to the developing baby; consult your doctor.

Pregnancy Category: D — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • May affect ability to drive
  • May cause aspermia (infertility) in males; amenorrhea in females
  • May cause inflammation of mouth and lips (stomatitis) and neurological toxicity
  • Avoid even accidental contamination of eyes
  • May cause acute kidney disease related to uric acid level
  • Consult doctor if pregnant or breastfeeding
Overdose effects

Symptoms: Bone marrow suppression, neurotoxicity.

Treatment: Supportive care.

Storage conditions

Store in a refrigerator (2°C-8°C). Keep vial in outer carton in order to protect from light.

Vinblastine — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.