৳ 35/unit
Pack: ৳ 350
৳ 35/unit
Pack: ৳ 350
At a glance
Voriconazole belongs to a group of medicines called antifungals. It works by stopping the growth of fungus and is used to treat a wide range of fungal infection. It kills fungi by destroying the fungal cell membrane.
Indications
- Severe fungal infections
- Invasive aspergillosis
- Candidemia
- Esophageal candidiasis
- Infections caused by Scedosporium apiospermum and Fusarium species
Pharmacology
Voriconazole is a triazole antifungal agent which inhibits cytochrome P450-dependent enzymes thereby inhibiting ergosterol synthesis in fungal cell membranes.
Dosage
Adult Dose (IV):
- Invasive Aspergillosis, Candidemia, Serious Fungal Infections: 6 mg/kg IV every 12 hours for first 24 hours, then 4 mg/kg IV every 12 hours or 200 mg PO every 12 hours
- Esophageal Candidiasis: 200 mg PO every 12 hours
- Hepatic impairment: Mild to moderate: standard loading dose but maintenance doses reduced by 50%
Child Dose (12 years and older) (IV):
- Invasive Aspergillosis, Candidemia, Serious Fungal Infections: 6 mg/kg IV every 12 hours for first 24 hours, then 4 mg/kg IV every 12 hours or 200 mg PO every 12 hours
Side effects
Common Side Effects:
- Abnormal liver function tests
- Hallucination
- Slow heart rate
- Altered vision
- Headache
- Nausea
- Rash
- Vomiting
Use in pregnancy
Use in Pregnancy: Unsafe; definite evidence of risk to the developing baby; consult your doctor.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May cause side effects which could affect your ability to drive
- May cause blurring of vision or uncomfortable sensitivity to light
- Liver function will be checked before and regularly during treatment
- Inform doctor if yellowing of eyes or skin, dark urine, or stomach pain occurs
- Consult doctor if pregnant, planning pregnancy or breastfeeding
Overdose effects
Symptoms: No data found.
Treatment: Supportive care.
Storage conditions
Keep out of reach of children. Store in a dry place, below 25°C temperature and protected from light. Store Voriconazole powder for suspension between 2° to 8°C temperature.