Voriconazole

Voriconazole belongs to a group of medicines called antifungals. It works by stopping the growth of fungus and is used to treat a wide range of fungal infection. It kills fungi by destroying the fungal cell membrane. Voriconazole should be taken in the dose and duration as prescribed by your doctor. It should be swallowed whole. It should be taken one hour before or one hour after a meal. The dosage and length of treatment will depend on the condition you are being treated for. Sometimes this will be in cycles of use and non-use. To get the most benefit, take this medicine at evenly spaced times and continue using it until your prescription is finished, even if your symptoms disappear after a few days. If you stop treatment too early, the infection may return and if you miss doses you can increase your risk of infections that are resistant to further treatment. Tell your doctor if the infection does not get better or if it gets worse. The most common side effects of this medicine include rash, vomiting, nausea, and headache. These are not usually serious, but you should call your doctor if you think you might have a severe allergic reaction. Signs of this include rash, swelling of the lips, throat or face, swallowing or breathing problems, feeling dizzy or faint and nausea. Get emergency help if this happens. Do not take it if you are pregnant or could become pregnant unless your doctor has told you to. Talk to your doctor before taking it if you have ever had heart failure, a weak immune system (including HIV/AIDS), kidney problems or liver problems such as yellow skin (jaundice). This medicine may not be suitable for you. If your course of treatment is for more than a month, your doctor may want to check your liver by testing your blood. This medicine may make you dizzy or have blurred vision so do not drive or operate machines until it is safe. Voriconazole is an antifungal medication. It kills and stops the growth of the fungi by destroying its cell membrane, thereby treating your skin infection.

• Severe fungal infections

Voriconazole is a triazole antifungal agent which inhibits cytochrome P450-dependent enzymes thereby inhibiting ergosterol synthesis in fungal cell membranes. It has a broad spectrum of activity against all Candida spp. including strains resistant to fluconazole), Aspergillus spp., Scedosporium spp., and Fusarium spp.

Adult Dose: Adult Invasive Aspergillosis, Candidemia, Serious Fungal Infections 6 mg/kg IV q12hr for first 24 hours, then 4 mg/kg IV q12hr or 200 mg PO q12hr Esophageal Candidiasis Candida albicans, Candida glabrata, Candida krusei 200 mg PO q12hr Hepatic impairment: Mild to moderate (Child-Pugh category A and B): Standard loading dose but maintenance doses should be reduced by 50%. Child Dose: 12 years Invasive Aspergillosis, Candidemia, Serious Fungal Infections 6 mg/kg IV q12hr for first 24 hours, then 4 mg/kg IV q12hr or 200 mg PO q12hr Esophageal Candidiasis Candida albicans, Candida glabrata, Candida krusei 200 mg PO q12hr

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Voriconazole is to be taken empty stomach.

Common: • Abnormal liver function tests • Hallucination • Slow heart rate • Altered vision • Headache • Nausea • Rash • Vomiting

[UNSAFE] Voriconazole may cause side effects which could affect your ability to drive. Voriconazole may cause blurring of vision or uncomfortable sensitivity to light and this may impair your ability to drive. Your doctor has prescribed Voriconazole to cure your infection and improve symptoms. Do not skip any doses and finish the full course of treatment even if you feel better. It should be taken one hour before or one hour after a meal. Do not take indigestion remedies (antacids) within two hours of taking Voriconazole. Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Hypersensitivity. Co-admin w/ CYP3A4 substrates, terfenadine, astemizole, cisapride, pimozide, quinidine, rifampicin, carbamazepine, long-acting barbiturates (e.g. phenobarbital, mephobarbital), ergot alkaloids (e.g. ergotamine and dihydroergotamine), efavirenz (≥400 mg once daily), ritonavir (≥400 mg bid), sirolimus, rifabutin, St John's wort.

Increased prothrombin time w/ oral anticoagulants. May increase plasma concentrations of ciclosporin and tacrolimus, long-acting opiates (e.g. oxycodone, methadone), NSAIDs (e.g. ibuprofen, diclofenac), omeprazole, short-acting opiates (e.g. alfentanil, fentanyl). Decreased voriconazole plasma concentration and increased phenytoin plasma concentrations when used concomitantly. May increase plasma concentration w/ oral contraceptives. Potentially Fatal: May increase risk of QT prolongation or torsades de pointes w/ astemizole, cisapride, pimozide, quinidine and terfenadine. May increase risk of ergotism w/ ergot alkaloids (e.g. ergotamine and dihydroergotamine). May significantly increase plasma concentrations of sirolimus. Decreased plasma concentrations w/ rifampicin, carbamazepine, long-acting barbiturates (e.g. phenobarbital, mephobarbital), efavirenz (?400 mg once daily), ritonavir (?400 mg bid). Concomitant use may significantly increase rifabutin and decrease voriconazole plasma concentration.

[UNSAFE] It is unsafe to consume alcohol with Voriconazole.

[CONSULT YOUR DOCTOR] Voriconazole is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[CONSULT YOUR DOCTOR] Voriconazole is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[SAFE IF PRESCRIBED] Voriconazole is safe to use in patients with kidney disease. No dose adjustment of Voriconazole is recommended. [CAUTION] Voriconazole should be used with caution in patients with liver disease. Dose adjustment of Voriconazole may be needed. Please consult your doctor. Regular monitoring of liver function tests is advised while you are taking this medicine.

Fungal infections in body and highly itching Take gandhak rasayan 2 tablet twice, aarogyavardhini vati 2 tablet twice, apply mahamarichyadi oil fungal infections about 4-5 year old Take gandhak rasayan 1 tablet twice, Nimbadi churan half spoon thrice, Apply Jatyadi oil on the area My doctor prescribed me an antifungal tablet named Vorizol 200mg which costs 3600 for a strip of 4 tab. Is there any substitute? Tell me the problem. Do u have any fungal sinusitis I have been experiencing fungal infections, I develop rings and rashes and they all itch like anything. I formed scars because of it. I have been taking Grisovin FP 250 mg however as long I take it I am relieved, even if I miss it for 1 day I start getting fungus back. On top of that Grisovin FP is difficult to find now, please suggest. You are having fungal infections severe, you need to change the medicine by skin specialistCan b prescribed under supervisionMeanwhile apply onabet cream twice a day Medicine for fungal infections. There is hundred type of fungal infectionFrom which you sufferBetter visit clinic for proper examination Fungal infections on body & face Cap. Itraconazole (Itrasys/ Canditral) 100mg twice daily for 2 weeks.Sertacide Cream for application twice daily for 1 month.Send pictures for better diagnosis and treatment How to treat fungal infections Stop all other applications. Cap. Itraconazole (Itrasys/ Canditral) 100mg twice daily for 2 weeks. Sertacide Cream for application twice daily for 1 month.Tab. Fexova 180 mg (if required in case of itching) Test ? Blood sugar ( Fasting & PP) The treatment has to be complete otherwise it will be recur. Fungal infections on thigh ittching Onabet cream twice a day meanwhile visit skin specialist for proper examination and treatment