Acemetacin

Acemetacin is a nonsteroidal anti-inflammatory. It is also known as a nonsteroidal anti-inflammatory drug. It works by inhibiting cyclooxygenase (also known as COX), a substance in the body that is involved in the production of irritant chemicals in response to injury or rheumatic disease. Acemetacin relieves pain and inflammation by inhibiting COX action. Acemetacin works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins. Prostaglandins are involved in a variety of bodily functions, including pain, inflammation, and fever. By inhibiting COX, acemetacin reduces the production of prostaglandins, which leads to a decrease in pain, inflammation, and fever.

Acemetacin use as a treatment of pain and inflammation.

Acemetacin is a nonselective inhibitor of pro-inflammatory mediators produced by the enzyme COX. COX is required for the synthesis of prostaglandin E2 and F2, molecules derived from fatty acids and stored in the cell membrane. Acetometacine is metabolized to produce its major metabolite, indometacin, which is a non-selective COX inhibitor with the ability to inhibit polymorphonuclear leukocyte motility and reduce cerebral flow by modulating the nitric oxide and vasoconstriction pathways.

Adult Dose: The usual starting dose of acemetacin is 60 mg three times a day. The maximum recommended daily dose is 180 mg. Child Dose: It has not been approved for use in children under the age of 18. Renal Dose: For patients with mild to moderate renal impairment (creatinine clearance ≥30 mL/min): The recommended starting dose of acemetacin is 60 mg twice a day. The maximum recommended daily dose is 120 mg. For patients with severe renal impairment (creatinine clearance <30 mL/min): Acemetacin is not recommended.

Take Acemetacinin the dose and duration prescribed by doctor. Swallow it whole. Don't chew, crush, or break it. Acemetacin should be taken with food.

Take Acemetacin as soon as you remember .If it is almost time for your next dose, skip the missed dose and take next dose at the regular time. Do not take two doses at the same time.

Sometimes it causes: • Diarrhea • Vomiting • Nausea • Abdominal pain • Dizziness • Drowsiness • Peptic ulceration • Heartburn • Indigestion • Stomach upset • Headache

[CAUTION] Acemetacin can have side effects that can impair ability to drive safely. such as: Dizziness ,Drowsiness, Blurred vision ,Confusion, Impaired coordination .It is best to avoid driving while taking Acemetacin .

Hypersensitivity to acemetacin or other NSAIDs: Acemetacin is contraindicated in people who are allergic to acemetacin or to other NSAIDs Active peptic ulcer disease or gastrointestinal bleeding: Acemetacin is contraindicated in people who have active peptic ulcer disease or gastrointestinal bleeding. Acemetacin is not recommended for people with a history of asthma, urticaria, or other allergic reactions to NSAIDs.

Anticoagulants: Acemetacin can increase the risk of bleeding when taken with anticoagulants, such as warfarin and heparin. Antiplatelet agents: Acemetacin can increase the risk of bleeding when taken with antiplatelet agents, such as aspirin and clopidogrel. Other NSAIDs: Acemetacin can increase the risk of side effects when taken with other NSAIDs, such as ibuprofen and naproxen. Methotrexate: Acemetacin can increase the blood levels of methotrexate, which can lead to an increased risk of side effects. Lithium: Acemetacin can increase the blood levels of lithium, which can lead to an increased risk of side effects. Digoxin: Acemetacin can increase the blood levels of digoxin, which can lead to an increased risk of side effects. Phenytoin: Acemetacin can decrease the blood levels of phenytoin, which can lead to a decreased effectiveness of phenytoin.

[UNSAFE] Alcohol can increase the risk of stomach upset and bleeding when taken with Acemetacin .

[CONSULT YOUR DOCTOR] Acemetacin is not recommended for use during pregnancy.

[UNSAFE] Acemetacin is not safe use during breastfeeding.

[CAUTION] Acemetacin should be used with caution in patients with renal impairment.In patients with severe kidney disease, Acemetacin is not recommended. [CAUTION] Acemetacinshould be used with caution in people with liver disease.The dose ofAcemetacin may need to be adjusted in people with liver disease.Acemetacincan cause liver damage, especially in people who take high doses of the medication for a long period of time.

Store at temperatures below 25°C. Protect against moisture and light .Keep out of the reach of children.