Amphotericin B

Fungistatic or fungicidal agent binding to ergosterol in fungal cell membranes, causing cell lysis.

Empirical therapy in febrile neutropenic patients, cryptococcal meningitis, refractory fungal infections, and visceral leishmaniasis.

Other Antifungal preparations

Polyene Antifungal

Binds irreversibly to ergosterol in fungal cell membranes, disrupting membrane integrity and causing cell death.

Creates transmembrane channels leading to leakage of intracellular components and cell death.

Test dose: 1 mg IV over 20-30 min. Load: 0.25-0.5 mg/kg IV. Maintenance: 0.25-1 mg/kg IV daily or up to 1.5 mg/kg every other day.

Administered by medically trained personnel. Reconstituted with 12 mL Sterile Water for Injection per vial to yield 4 mg/mL suspension.

Administered in clinical settings as scheduled.

Fever, chills, convulsions, nausea, vomiting, diarrhea, hypotension, hypertension, arrhythmias, renal toxicity.

Must be administered by medically trained personnel under close clinical observation.

Known hypersensitivity to amphotericin B components.

Increased toxicity with flucytosine and nephrotoxic drugs. Antagonizes azole antifungals.

Not applicable.

Pregnancy Category B. Use if benefits outweigh risks.

Pregnancy Category: B — always consult a doctor before taking during pregnancy.

Excretion in human milk is unknown.

Use with caution under medical supervision.

Use with caution under medical supervision.

Monitor renal function closely due to potential nephrotoxicity.

Supportive care with cardiovascular and respiratory monitoring.

Store unopened vials up to 25°C. Reconstituted product stable for 24 hours at 2-8°C.

Amphotericin B macrolide structure