Generic
Calcium + Vitamin D3 + Minerals
2 brands available in the market
At a glance
Calcium + Vitamin D3 + Minerals is a combination supplement used for the prevention and treatment of osteoporosis, maintaining strong bone growth, and supplementing deficiencies of calcium, vitamin D3, and minerals. It supports proper functioning of the heart, muscles, and nerves.
Description
Calcium + Vitamin D3 + Minerals is a nutritional supplement that plays an important role in preventing osteoporosis and other bone-related diseases. Calcium, magnesium, and vitamin D3 are the macronutrients for bone health. Very little calcium is absorbed without vitamin D3. Like calcium, magnesium increases bone strength and rigidity.
Each film-coated tablet contains: Calcium Carbonate USP 1500 mg (equivalent to 600 mg elemental Calcium), Cholecalciferol BP 2 mg (equivalent to 200 IU Vitamin D3), Magnesium Oxide USP 66.34 mg (equivalent to 40 mg Magnesium), Zinc Oxide USP 9.34 mg (equivalent to 7.5 mg Zinc), Cupric Oxide 1.25 mg (equivalent to 1 mg Copper), Manganese Sulfate Monohydrate 5.54 mg (equivalent to 1.8 mg Manganese), and Boron Citrate 5 mg (equivalent to 0.25 mg Boron). Effervescent tablets contain 400 IU Vitamin D3.
Indications
- Prevention and treatment of osteoporosis
- To maintain strong bone growth
- Proper functioning of heart, muscle and nerves
- Nutritional supplement
- Bone development and regeneration of bone
- Pregnancy & lactation
- Deficiency of Calcium, Vitamin D3, Magnesium, Zinc, Copper, Manganese & Boron
Therapeutic class
Specific mineral & vitamin combined preparations
Pharmacological class
Nutritional Supplement (Calcium + Vitamin D3 + Minerals)
Pharmacology
Calcium is the primary mineral component of bones, providing strength and rigidity. Vitamin D3 enhances intestinal calcium absorption and regulates bone mineralization. Magnesium increases bone strength and aids calcium metabolism. Zinc, copper, manganese, and boron are micronutrients essential for bone health. Deficiencies of these micronutrients are observed in patients with osteoporosis.
Mechanism of action
Calcium supports bone mineralization. Vitamin D3 enhances calcium absorption and stimulates bone formation. Magnesium increases bone strength. Zinc, copper, manganese, and boron help maintain bone health.
Dosage
Adolescents and adults: 1 tablet once or twice daily (effervescent or film-coated) or as directed by a physician.
Children: 1 tablet once daily.
Renal stones history: Dose should be reduced or adjusted.
Note: Allowances should be made for calcium and vitamin D3 supplements from other sources.
Administration
Effervescent tablet: Dissolve in a glass of water and drink immediately. Do not swallow or chew the tablet. Film-coated tablet: Take with or just after meals with a full glass of water. Follow the dose and duration as advised by your physician.
Missed dose
If you miss a dose, take it as soon as you remember. Skip the missed dose if it is almost time for your next dose. Do not double the dose.
Side effects
Common (less serious): Nausea, vomiting, diarrhea, abdominal pain, constipation, flatulence, bloating, itching, redness/burning of the skin.
Rare: Hypercalcemia, hypercalciuria.
Very rare: Serious allergic reaction (swelling of the face, lips, tongue, and throat).
Precautions & warnings
- Patients with mild to moderate renal failure or mild hypercalciuria should be supervised carefully.
- Periodic checks of plasma calcium levels and urinary calcium excretion should be made.
- In patients with a history of renal stones, urinary calcium excretion should be measured to exclude hypercalciuria.
- With long-term treatment, monitor serum and urinary calcium levels and kidney function; reduce or stop treatment temporarily if urinary calcium exceeds 7.5 mmol/24 hours.
Contraindications
- Hypercalcemia resulting from myeloma, bone metastasis or other malignant bone disease, sarcoidosis, primary hyperparathyroidism, and vitamin D3 overdosage
- Severe renal failure
- Hypersensitivity to any of the ingredients
- Relative contraindications: osteoporosis due to prolonged immobilization, renal stones, severe hypercalciuria
Drug interactions
- Cardiac glycosides (digitalis): Physician supervision required; hypocalcemia must be avoided.
- Thiazide diuretics: Reduce urinary calcium excretion, increasing risk of hypercalcemia.
- Corticosteroids: Physician supervision required.
- Bisphosphonates, sodium fluoride: Take calcium supplement at least 3 hours after these drugs.
- Tetracycline, cholestyramine, laxatives: Take calcium 1-2 hours before or 4-6 hours after these drugs.
- Foods containing oxalic acid, phosphate, or phytic acid: May reduce calcium absorption.
Food interactions
Oxalic acid (spinach, rhubarb), phosphate, and phytic acid (grains) may reduce calcium absorption.
Use in pregnancy
Can be used during pregnancy in case of calcium and vitamin D deficiency. For supplementation starting during the third trimester, daily intake should not exceed 1500 mg calcium and 1000 IU vitamin D.
Use in lactation
Can be used during breastfeeding under medical supervision.
Pediatric use
Geriatric use
Safe for elderly; particularly beneficial for osteoporosis prevention.
Renal / hepatic impairment
Hepatic impairment: No special precautions required, but consult your physician.
Overdose effects
Overdose symptoms: Nausea, vomiting, severe drowsiness, dry mouth, loss of appetite, metallic taste, stomach cramps, diarrhea, headache, constipation.
Storage conditions
Store in a dry place away from light and heat. Keep out of reach of children.
Chemical structure
Calcium Carbonate 1500 mg (equiv. Calcium 600 mg) + Cholecalciferol 2 mg/4 mg (Vitamin D3 200/400 IU) + Magnesium Oxide 66.34 mg + Zinc Oxide 9.34 mg + Cupric Oxide 1.25 mg + Manganese Sulfate 5.54 mg + Boron Citrate 5 mg