Generic
Ibuprofen (Gel)
1 brands available in the market
At a glance
Ibuprofen Gel is a topical NSAID used for muscle and joint pain, sprains, arthritis and sports injuries.
Description
Ibuprofen Gel is a topical non-steroidal anti-inflammatory drug (NSAID) that exerts its anti-inflammatory and analgesic effects directly in inflamed tissues underlying the site of application, mainly by inhibiting prostaglandin biosynthesis. Because it is formulated in an aqueous or alcoholic gel, it also exerts a soothing and cooling effect when applied to the affected area.
Indications
- Rheumatic pain
- Joint pain
- Muscle pain
- Back pain
- Sprains and strains
- Sports injury
Therapeutic class
Topical analgesic & anti-inflammatory gel
Pharmacological class
Non-steroidal anti-inflammatory drug (topical)
Pharmacology
Ibuprofen is a phenylpropionic acid derivative which exerts its anti-inflammatory and analgesic effects directly in inflamed tissues underlying the site of application, mainly by inhibiting prostaglandin biosynthesis. It inhibits cyclo-oxygenase (COX) enzymes, reducing local prostaglandins and thereby local pain and inflammation.
Mechanism of action
Inhibits COX enzymes to reduce local prostaglandin synthesis, resulting in relief of pain and inflammation at the application site.
Dosage
Adult Dose (Topical):
- Gently massage a small amount into affected area 3-4 times daily
- Use 1-4 cm each time
- Do not use more often than every 4 hours
- Do not use for more than 2 weeks without medical advice
Child Dose: For patients over 14 years; safety and efficacy not established in children under 14 years
Administration
For external use only; try on a small area first; apply a thin layer over the affected area; gently rub until absorbed; wash hands after use; avoid broken skin, eyes and mucous membranes.
Missed dose
If you miss a dose, apply when remembered; do not apply extra to catch up.
Side effects
Common Side Effects:
- Mild redness at application site
- Itching
- Burning
Occasional: Unexplained wheezing, shortness of breath, blisters or rash, itching, redness or bruising of skin, swelling of face
Precautions & warnings
Precautions:
- Caution if allergic to aspirin/NSAIDs or if asthmatic
- Avoid heavy use over large areas
- Apply with gentle massage only
- Avoid contact with eyes, mucous membranes and inflamed or broken skin
- Discontinue if rash develops
- Not for use with occlusive dressings
- Caution in kidney problems or stomach ulcer
- Avoid getting near eyes, lips, nostrils, genital areas; if accidental, wash with plenty of water
Contraindications
Contraindications:
- Known hypersensitivity to ibuprofen, aspirin or other NSAIDs
- Asthma, rhinitis, itching or rashes
- Do not apply to wounds
Drug interactions
Drug Interactions:
- Systemic absorption is low with topical use; still avoid combining with other NSAIDs excessively
- Consult physician if taking aspirin, any other pain relieving medicine or other medicines regularly
Food interactions
Food interactions not applicable (external use).
Use in pregnancy
Use in Pregnancy: Avoid in the third trimester; use only on medical advice; Pregnancy Category C.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Short-term use on a small area is generally acceptable; seek advice; do not use if more than 6 months pregnant or breastfeeding.
Pediatric use
Not recommended for children under 14 years.
Geriatric use
No specific dosage adjustment needed for elderly; however caution is advised.
Renal / hepatic impairment
Caution in kidney problems or stomach ulcer; consult your doctor.
Overdose effects
Overdose with topical ibuprofen is unlikely; accidental oral ingestion may cause headache, vomiting, drowsiness, hypotension; correction of severe electrolyte abnormalities should be considered.
Storage conditions
Store in a cool (below 30°C) and dry place protected from light; keep away from fire; keep out of reach of children.
Chemical structure
Ibuprofen Gel