Itraconazole

Itraconazole belongs to a group of medicines called antifungals. It works by stopping the growth of fungus and is used to treat infections of the mouth, throat, vagina and other parts of the body including fingernails and toenails. It kills fungi by destroying the fungal cell membrane. Itraconazole should be taken in the dose and duration as prescribed by your doctor. It should be swallowed whole and can be taken with food. The dosage and length of treatment will depend on the condition you are being treated for. Sometimes this will be in cycles of use and non-use. To get the most benefit, take this medicine at evenly spaced times and continue using it until your prescription is finished, even if your symptoms disappear after a few days. If you stop the treatment too early, the infection may return and if you miss doses you can increase your risk of infections that are resistant to further treatment. Tell your doctor if the infection does not get better or if it gets worse. Avoid taking antacid medications within one hour before or two hours after you take this medicine. The most common side effects of this medicine include stomach pain, headache and feeling sick (nausea). You may also experience problems with menstrual periods, runny nose, indigestion, blurred vision, hearing loss, constipation, diarrhea and cough and cold. You could ask your doctor about ways of preventing or reducing these effects. Get emergency medical help if you have signs of an allergic reaction like severe skin rash, tingling, difficulty breathing, swelling of your face, lips, tongue, or throat. Stop using this medicine and contact your doctor if you notice signs of congestive heart failure like, feeling tired or short of breath, cough with mucus, fast heartbeats, swelling, rapid weight gain, or sleep problems. Do not take it if you are pregnant or could become pregnant unless your doctor has told you to. Talk to your doctor before taking this medicine if you have ever had heart failure, a weak immune system (including HIV/AIDS), kidney problems or liver problems such as yellow skin (jaundice). This medicine may not be suitable for you. If your course of treatment is for more than a month, your doctor may want to check your liver by testing your blood. This medicine may make you dizzy or cause blurred vision so do not drive or operate machines until it is safe. Itraconazole is an antifungal medication. It kills fungi by destroying the fungal cell membrane. This treats your skin infection.

• Fungal infections

Itraconazole decreases ergosterol synthesis by interfering w/ cytochrome P450 activity. This inhibits cell membrane function of susceptible fungi including Microsporum spp., Trichophyton spp., Candida spp., Aspergillus spp., Epidermophyton spp., Cryptococcus neoformans, Histoplasma capsulatum, Blastomyces dermatitidis, sporothrix schenckii, Malassezia furfur, Coccidioides immitis and Paracoccidiodes brasiliensis. It also has antiprotozoal activity against Leishmania spp.

Adult Dose: Oral Adult: PO: Oropharyngeal candidiasis As cap: 100 mg/day for 15 days. Vulvovaginal candidiasis As cap: 200 mg twice daily for 1 day. Pityriasis versicolor As cap: 200 mg/day for 7 days. Tinea corporis; Tinea cruris As cap: 100 mg/day for 15 days. Fungal nail infections As cap: 200 mg/day for 3 mth. Systemic fungal infections As cap: 100-200 mg once daily, up to 200 mg twice daily for invasive or disseminated infections. Prophylaxis of infections in neutropenic or AIDS patients As cap: 200 mg/day, up to 200 mg twice daily if needed. Tinea pedis; Tinea manuum As cap: 100 mg/day for 30 days or 200 mg bid for 7 days. Child Dose: Child: PO 10 mg/kg/day, max 200 mg/day q12h 5 mg/kg/day for chronic mucocutaneous Candida q24h <3 years: Safety and efficacy not established

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Itraconazole is to be taken with food.

If you miss a dose of Itraconazole, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Nausea • Common cold • Cough • Blurred vision • Menstrual disorder

[UNSAFE] Itraconazole may cause side effects which could affect your ability to drive. Itraconazole can sometimes cause dizziness, blurred/double vision or hearing loss. This may affect your ability to drive. Itraconazole helps treat fungal infections of mouth, skin, vagina or any other parts of the body. Do not skip any doses and finish the full course of treatment even if you feel better. Take it with food, preferably at the same time everyday. Use a reliable method of contraception to prevent pregnancy while taking this medicine. Do not take indigestion remedies (antacids) within two hours of taking Itraconazole. Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain. Inform your doctor if you develop allergic reactions, nerve pain, or hearing loss.

Hypersensitivity to azole antifungals; pregnancy and lactation; hepatic disease. IV: CrCl: <30 ml/min.

May increase the plasma concentrations of oral anticoagulants, digoxin, cilostazol, alprazolam, midazolam (IV), repaglinide, corticosteroids (e.g. budesonide, dexamethasone, fluticasone, methylprednisolone). May increase plasma concentration w/ HIV protease inhibitors (e.g. ritonavir, indinavir, saquinavir), erythromycin, clarithromycin. May reduce plasma concentration w/ isoniazid, carbamazepine, nevirapine, phenytoin, Phenobarbital, rifampicin, rifabutin. May reduce absorption w/ PPIs, antacids, antimuscarinics, histamine H2 receptor antagonists. Concomitant use w/ dihydropyridines may cause oedema. May increase negative inotropic effects of verapamil. May increase risk of potentially fatal resp depression w/ fentanyl. Potentially Fatal: May increase risk of QT prolongation or torsades de pointes w/ astemizole, bepridil, cisapride, dofetilide, levacetylmethadol (levomethadyl), mizolastine, pimozide, quinidine, sertindole, terfenadine, methadone, ranolazine, dronedarone, halofantrine. May increase risk of myopathy including rhabdomyolysis w/ HMG-CoA reductase inhibitors (e.g. atorvastatin, lovastatin, simvastatin). May increase risk of ergotism w/ ergot alkaloids (e.g. ergotamine, dihydroergotamine, ergometrine, methylergometrine). May potentiate hypnotic and sedative effect of triazolam and oral midazolam. May increase plasma concentration of eletriptan, nisoldipine, felodipine, disopyramide, irinotecan, lurasidone; colchicine (patient w/ renal or hepatic failure). May increase risk of hypotension and hyperkalaemia w/ eplerenone.

[CAUTION] Caution is advised when consuming alcohol with Itraconazole. Please consult your doctor.

[CONSULT YOUR DOCTOR] Itraconazole may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Itraconazole is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[CONSULT YOUR DOCTOR] There is limited information available on the use of Itraconazole in patients with kidney disease. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Itraconazole in patients with liver disease. Please consult your doctor. Inform your doctor if you develop signs of jaundice like yellowing of eyes and skin, itching, and clay colored stools while taking this medicine.

Medicine for fungal infections. There is hundred type of fungal infectionFrom which you sufferBetter visit clinic for proper examination Fungal infections on body & face Cap. Itraconazole (Itrasys/ Canditral) 100mg twice daily for 2 weeks.Sertacide Cream for application twice daily for 1 month.Send pictures for better diagnosis and treatment How to treat fungal infections Stop all other applications. Cap. Itraconazole (Itrasys/ Canditral) 100mg twice daily for 2 weeks. Sertacide Cream for application twice daily for 1 month.Tab. Fexova 180 mg (if required in case of itching) Test ? Blood sugar ( Fasting & PP) The treatment has to be complete otherwise it will be recur. Fungal infections on thigh ittching Onabet cream twice a day meanwhile visit skin specialist for proper examination and treatment I am regularly using the cream cosmelite But now due to a fungal infection i have to use a antifungal cream fungicros So So i want to know whether i can apply the cream cosmelite after fungicros Pls tell me which part of body have fungal infections What kind of antibiotics should be taken for groin fungal infection along with the micanazole cream? Antibiotic is not required for fungal infection, antifungals like itraconazole, terbinafine, etc are used for fungal infections Diagonosed as candida infection by a dermatologist. not able to get rid from last 6 month. given me fluconozole Syntran 200 course twice Spornax course for a month(4 caps at an interval of 10 days). But infection is still there. post pictures of the problem Fungal infections on face and body Cap. Itraconazole (Itrasys/ Canditral) 100mg twice daily for 2 weeks. Sertacide Cream for application twice daily for 1 month.Tab. Fexova 180 mg (if required in case of itching)