Generic
Lidocaine (Lignocaine) Hydrochloride
9 brands available in the market
At a glance
Lidocaine (Lignocaine) Hydrochloride is a local anesthetic used to temporarily numb certain areas of the body. It is used as an anesthetic lubricant for insertion of instruments in medical procedures and for treatment of painful inflammation of the urethra and bladder.
Description
Lidocaine is an amide type local anesthetic. It stabilises the neuronal membrane and inhibits Na+ ion movements, which are necessary for conduction of impulses. In the heart, lidocaine reduces depolarisation of the ventricles during diastole and automaticity in the His-Purkinje system.
Indications
- Local anesthesia (numb tissues in a specific area)
- Treatment of painful inflammation of the urethra and bladder
- Anesthetic lubricant for medical procedures (e.g., catheters)
Therapeutic class
Local & Surface Anesthesia
Pharmacological class
Amide Local Anesthetic
Pharmacology
Lidocaine stabilizes the neuronal membrane and inhibits Na+ ion movements to block pain signals from nerves to the brain.
Mechanism of action
Works on the skin by blocking pain signals from the nerves to the brain, numbing the area and decreasing pain sensation.
Dosage
Adult Dose (IV - Ventricular Arrhythmias):
- Bolus: 1-1.5 mg/kg slow IV over 2-3 minutes
- Repeat: 0.5-0.75 mg/kg in 5-10 minutes, up to 3 mg/kg total
- Continuous infusion: 1-4 mg/min IV
Regional Anesthesia (IV): 4 mg/kg
Epidural: Lumbar: 250-300 mg; Thoracic: 200-300 mg; Caudal (Obstetric): 200-300 mg
Administration
- For external use only (gel/spray form)
- Use in the dose and duration as advised
- Check label for directions before use
- Clean and dry the affected area before application
Missed dose
Not applicable (use as needed); consult doctor if needed.
Side effects
Common Side Effects:
- Allergic reaction
- Application site reactions (burning, irritation, itching, and redness)
Precautions & warnings
- Do not apply to broken or infected skin
- Avoid contact with eyes, mouth, and nose
- Do not cover with airtight dressings (risk of side effects)
- Consult doctor if no improvement in 2-4 weeks
- Inform doctor if you have liver disease or heart rhythm problems
Contraindications
- Hypovolaemia
- Heart block or other conduction disturbances
Drug interactions
- May increase serum levels with cimetidine and propranolol
- Increased risk of cardiac depression with beta-blockers and other antiarrhythmics
- Additive cardiac effects with IV phenytoin
- Hypokalaemia caused by acetazolamide, loop diuretics, and thiazides may antagonise effect of lidocaine
Food interactions
No food interactions found.
Use in pregnancy
Use in Pregnancy: Lidocaine (Lignocaine) Hydrochloride is generally considered safe during pregnancy. Animal studies have shown low or no adverse effects to the developing baby.
Use in lactation
Use in Lactation: Lidocaine (Lignocaine) Hydrochloride is probably safe during breastfeeding. Limited human data suggests no significant risk to the baby.
Pediatric use
Use with caution in children (closely observe prescribed dose and treatment duration).
Geriatric use
Use with caution in elderly.
Renal / hepatic impairment
Hepatic Impairment: Dosage reduction may be needed in liver disease.
Overdose effects
No specific overdose information available; symptomatic and supportive measures should be employed.
Storage conditions
Store below 30°C in a dry place, away from light; keep out of reach of children.
Chemical structure
Lidocaine (Lignocaine) Hydrochloride