Generic
Neomycin Sulfate + Bacitracin Zinc + Polymyxin B Sulfate
1 brands available in the market
At a glance
Neomycin Sulfate + Bacitracin Zinc + Polymyxin B Sulfate is a combination topical antibiotic ointment used for infected wounds, burns, skin grafts, furuncles, carbuncles, pyoderma, impetigo and acne.
Description
This combination is effective against virtually all pathogenic bacteria. Polymyxin B sulfate is effective against gram-negative bacilli including Pseudomonas aeruginosa. Neomycin provides bactericidal action against various gram-positive and gram-negative organisms including Proteus and is most effective against Staphylococcus aureus. Bacitracin zinc is highly active against gram-positive bacilli and cocci.
Indications
- Infected wounds
- Burns
- Skin grafts
- Donor site preparation
- Chronic varicose or indolent ulcers
- Furuncles, carbuncles
- Pyoderma, sycosis barbae
- Impetigo, acne
- Secondary infected skin lesions of scabies, pediculosis, tinea pedis
Therapeutic class
Topical Antibiotic Preparations
Pharmacological class
Topical Antibiotic Combination
Pharmacology
Polymyxin B sulfate interacts with phospholipid components of bacterial cell membrane to produce bactericidal effect. Neomycin binds to 30S ribosomal subunit to inhibit protein synthesis. Bacitracin zinc inhibits bacterial cell wall synthesis.
Mechanism of action
Treats skin infections by inhibiting bacterial protein synthesis and cell wall formation.
Dosage
Adult Dose (Topical):
- Apply a thin layer to affected area 1-3 times daily
- Continue until infection is controlled and healing complete
Pediatric Dose: Same as adults; however, not recommended for neonates
Administration
- For external use only
- Clean affected area before application
- Apply thin layer
Missed dose
If you miss a dose, apply it as soon as you remember; skip if it's almost time for next dose; do not double the dose.
Side effects
Side Effects:
- Nausea, vomiting
- Pain, burning or swelling
- Skin rashes
- Kidney problems
- Hearing loss
- Dizziness
- Unusual numbness of skin
- Muscle twitching
- Seizures
Precautions & warnings
- Not intended for sterile use in surgical procedures (may potentiate neuromuscular block)
- Prolonged use may result in overgrowth of non-susceptible organisms
- Enhanced absorption in neonates and infants with immature renal function
Contraindications
- Hypersensitivity
- Neonates
Drug interactions
No known interactions (topical use).
Food interactions
No food interactions (topical use).
Use in pregnancy
Use in Pregnancy: Little information on topical neomycin in pregnancy; not recommended in pregnancy.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Little information on topical neomycin in lactation; not recommended in lactation.
Pediatric use
Not recommended for neonates; dose should be reduced in infants.
Geriatric use
Safe for elderly.
Renal / hepatic impairment
Renal Impairment: Caution in kidney disease; dose adjustment may be needed.
Hepatic Impairment: Caution in liver disease; dose adjustment may be needed.
Overdose effects
Overdose unlikely (topical use); symptomatic treatment.
Storage conditions
Store below 30°C; keep out of reach of children.
Chemical structure
Neomycin + Bacitracin + Polymyxin B Ointment