Tacrolimus 0.1%, 0.03% Topical

Tacrolimus 0.1%, 0.03% Topical is used to treat eczema (atopic dermatitis). It works by suppressing the activity of certain immune cells that cause inflammation (redness and swelling) of the skin. This relieves itching and improves rashes in atopic dermatitis. Tacrolimus 0.1%, 0.03% Topical is used for external use. It should be used 2-4 times a day on the affected area or use it as suggested by the doctor. It should be applied slowly and evenly to the skin until it is rubbed in. You should not use it too often and you should not cover the treated area with a bandage or plaster. You must inform your doctor if there's no improvement even after two weeks of treatment or if the skin gets worse. It is a safe medicine with few side effects, but you may get an application site reaction like burning, irritation, itching and redness. This medicine is not normally recommended during pregnancy or while breastfeeding unless it is clearly needed. Tacrolimus 0.1%, 0.03% Topical is an immunosuppressant. It works by suppressing the activity of certain immune cells that cause inflammation (redness and swelling) of the skin. This relieves itching and improves rashes in atopic dermatitis.

Atopic dermatitis, Allergic contact dermatitis, Severe eczema, Psoriasis, Alopecia areata, Pyoderma gangrenosum, Cutaneous lupus erythematosus, Dermatomyositis, Seborrheic dermatitis, Rosacea, Lichen Planus, Pemphigus Vulgaris, Vitiligo, Graft-Versus-Host Disease, Ichthyosis.

Tacrolimus inhibits T-lymphocyte activation, although the exact mechanism of action unclear. Tacrolimus bind to cytosolic receptors known as immunophilins (i.e., cyclophilin and FK binding protein-12 [FKBP-12], respectively), forming complexes that inhibit the production of cytokines via the calcineurin pathway. Inhibition of calcineurin activity inhibits early activation of T-cells (ie.immunosuppresion results).

Adult Dose: Topical/Cutaneous Atopic dermatitis Adult: Apply thinly 0.03% or 0.1% ointment to affected area bid. Rub in gently and completely. For short-term and intermittent use only. If no improvement after 6 wk, re-confirm diagnosis. Child Dose: Topical/Cutaneous Atopic dermatitis 15 years: Apply 0.03% or 0.1% ointment as thin layer to affected area q12hr;

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and gently massage the ointment.

If you miss a dose of Tacrolimus 0.1%, 0.03% Topical, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Application site reactions (burning, irritation, itching and redness)

No interaction found/established Tacrolimus 0.1%, 0.03% Topical is effective at treating eczema (atopic dermatitis) when other treatment options have failed. It works by decreasing itching, redness, and skin rashes. Apply thinly, to affected areas of skin only. Clean the affected area and dry well before applying Tacrolimus 0.1%, 0.03% Topical. Avoid contact with water after application. Inform your doctor if there's no improvement even after two weeks of treatment, or if the skin gets worse. Don't cover the area being treated with airtight dressings such as bandages unless directed by a doctor, as this may increase the risk of side effects. Stop using Tacrolimus 0.1%, 0.03% Topical and consult your doctor if your eczema becomes infected. Continuous long-term use of the ointment should be avoided. Use as prescribed by you doctor.

Tacrolimus ointment is contraindicated in patients with a history of hypersensitivity to Tacrolimus or any other component of the preparation.

Increased nephrotoxicity with ciclosporin, aminoglycosides, amphotericin B, cisplatin, NSAIDs, vancomycin, co-trimoxazole, aciclovir, ganciclovir. Increased risk of hyperkalemia with potassium-sparing diuretics. Increased plasma concentrations and toxicity with azole antifungals, calcium-channel blockers, cimetidine, danazol, HIV-protease inhibitors, macrolide antibacterials and metoclopramide. Antacids, rifampin, rifabutin, casofungin, phenytoin, phenobarbital and carbamazepine decrease tacrolimus plasma concentrations. Concurrent admin of sirolimus and tacrolimus decrease levels of both.

No interaction found/established

[CONSULT YOUR DOCTOR] Tacrolimus 0.1%, 0.03% Topical may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Tacrolimus 0.1%, 0.03% Topical is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

No interaction found/established No interaction found/established

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