Tenecteplase

Tenecteplase belongs to a group of medicines called thrombolytic agents. It is used in the emergency treatment of heart attack. It helps to dissolve blood clots that have formed in the blood vessels of the heart. Tenecteplase is an injectable drug, given directly into a vein and it is given by a doctor as soon as possible after the first signs of a heart attack. Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely. You may be given another medicine to stop blood clotting at the same time or after the treatment. This medicine may increase your risk of bleeding, so its better to be careful while shaving, cutting nails, or using sharp objects. Treatment with this drug can also cause nausea, vomiting, decreased blood pressure, and injection site bleeding. This drug needs to be administered with care by an expert and is not suitable for everyone. There is a long list of situations where you will not be given Tenecteplase including if you've had a head injury, or surgery on your brain or spinal cord and any current bleeding anywhere in your body. Your healthcare team will need to know a lot about your medical history before giving you this medicine. Tenecteplase is a thrombolytic medication. It works by dissolving the harmful blood clots in the blood vessels. This restores the blood flow to the affected tissue, thereby preventing tissue death and improving outcomes.

• Heart attack

Tenecteplase is a biosynthetic form of the enzyme human tissue-type plasminogen activator (t-PA). It is a fibrin-specific thrombolytic, converts plasminogen to plasmin, a proteolytic enzyme that has fibrinolytic effects.

Adult Dose: Intravenous Acute myocardial infarction Adult: 30-50 mg as a single bolus dose over 5-10 sec as soon as possible after the onset of symptoms. The dose is based on body weight. Max: 50mg. Administer ASAP (within 30 minutes) after onset of acute MI 30-50 mg IV bolus over 5 sec once (based on weight) 90 kg: 50 mg

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Common: • Injection site bleeding • Nosebleeds • Blood in stool • Blood in urine • Gastrointestinal bleeding

[NOT RELEVANT] Not relevant, as Tenecteplase is intended for use in hospitalised patients. Tenecteplase is used to treat myocardial infarctions (heart attacks) as soon as possible (usually within 12 hours) after the onset of symptoms. It is given as an injection into the vein under the supervision of a doctor. It may increase your risk of bleeding. Inform your doctor immediately if you notice bleeding at the injection site, nose bleed, and blood in urine. Continue with your diet and exercise along with previously prescribed medications for heart attack.

Patients at risk of cerebral bleeding including severe hypertension, history of stroke, intracranial or intraspinal surgery or trauma within 2 mth, arteriovenous malformation or aneurysm, cerebral neoplasm. Haemorrhage or known bleeding diathesis.

Increased risk of haemorrhage with heparin, oral anticoagulants, antiplatelet drugs and other drugs that can affect platelet function.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Tenecteplase. Please consult your doctor.

[CONSULT YOUR DOCTOR] Tenecteplase may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CAUTION] Tenecteplase should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.

[CONSULT YOUR DOCTOR] There is limited information available on the use of Tenecteplase in patients with kidney disease. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Tenecteplase in patients with liver disease. Please consult your doctor.

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