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Thioridazine hydrochloride

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Melleril10mgNevian Lifescience PLCTablet৳ 1
Melleril25mgRainbow TradersTablet

At a glance

Thioridazine hydrochloride — brands, prices, indication, dosage and side effects available in Bangladesh.

Description

Thioridazine hydrochloride is a prescription medicine used in the treatment of schizophrenia. It alters the thoughts and elevates the mood, improving the person’s ability to think, feel and behave. Thioridazine hydrochloride should be taken with food, preferably at the same time each day. Take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember it. Do not skip any doses and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to your doctor as it may worsen your symptoms. Some common side effects of this medicine include dry mouth, abnormality of voluntary movements, urinary retention, constipation, and muscle rigidity. Initially, this medicine may cause a sudden drop in blood pressure when you change positions, rise slowly if you have been sitting or lying down. It may also cause dizziness and sleepiness, do not drive or do anything that requires mental focus until you know how this medicine affects you. Before taking it, inform your doctor if you are suffering from thyroid or kidney problems, epilepsy, Parkinson's disease, glaucoma, or any heart problems. You should not take this medicine if you are under the influence of alcohol or any sleep-inducing, cough, and/ or allergy medication. This medicine can also lead to weight gain, eat a healthy balanced diet, avoid snacking with high-calorie food, and exercise regularly. Thioridazine hydrochloride is a typical antipsychotic. It works by blocking the action of dopamine, a chemical messenger in the brain that affects thoughts and mood.

Indications

• Schizophrenia

Mechanism of action

Thioridazine, a phenothiazine antipsychotic, exhibits strong beta-adrenergic blocking effects and depresses the release of hypothalamic and hypophyseal hormones by blocking postsynaptic mesolimbic, dopaminergic receptors in the brain.

Dosage

Adult Dose: Oral Schizophrenia Adult: Initially, 50-100 mg tid, gradually increased if necessary in increments of not more than 100 mg wkly. Usual daily dose: 200-800 mg in 2-4 divided doses. Max: 800 mg daily. Depressive Disorders Adult: Initially, 25 mg tid, titrated to 20-200 mg daily. Hepatic impairment: Lower initial doses and more gradual dosage increase. Child Dose: Oral Schizophrenia Child: 2-12 yr: Initially, 0.5 mg/kg daily in divided doses, increased gradually until optimum effect obtained. Max: 3 mg/kg daily. >12 years: Initial 50-100 mg PO q8hr; titrate to 200-800 mg/day PO divided q6-12hr Renal Dose: Renal impairment: Lower initial doses and more gradual dosage increase.

Administration

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Thioridazine hydrochloride is to be taken with food.

Side effects

Common: • Orthostatic hypotension (sudden lowering of blood pressure on standing) • Sleepiness • Dryness in mouth • Abnormality of voluntary movements • Weight gain • Increased prolactin level in blood • Urinary retention • Constipation • Muscle stiffness • Tremor

Precautions & warnings

[UNSAFE] Thioridazine hydrochloride may cause side effects which could affect your ability to drive. As Thioridazine hydrochloride may impair your thinking or reactions. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy and this may affect your ability to drive. Thioridazine hydrochloride should be taken with food, preferably at the same time every day. It may increase your weight, blood sugar and cholesterol. Eat healthy, exercise regularly and monitor your blood levels regularly. Use caution while driving or doing anything that requires concentration as Thioridazine hydrochloride can cause dizziness and sleepiness. Get regular eye examinations while taking this medicine, as it can sometimes cause eye problems. Get regular blood tests to monitor the levels of electrolytes (salts such as potassium and magnesium) in your blood as suggested by your doctor. Regularly get your heart function monitored as suggested by your doctor. Inform your doctor if you experience any abnormal movements, particularly of the face, lips, jaw and tongue, while taking this medicine.

Contraindications

Hypersensitivity to phenothiazines, comatose states, pre-exisitng CNS depression, severe CVS disorders, uncorrected hypokalaemia or any electrolyte imbalance, known or suspected QT prolongation, history of ventricular arrhythmias including torsades de pointes and porphyria. Bone-marrow suppression, phaeochromocytoma, or prolactin-dependent tumours, angle-closure glaucoma, history of jaundice, parkinsonism, DM, hypothyroidism, myasthenia gravis, paralytic ileus, prostatic hyperplasia, or urinary retention. Patients with reduced activity of cytochrome P450 isoenzyme CYP2D6.

Drug interactions

Potentiates adverse effects of anticholinergics. Concurrent use of TCAs leads to raised blood levels of both drugs. May antagonise effects of levodopa, bromocriptine and other dopamine agonists. Avoid co-admin with drugs that cause electrolyte imbalance. Monitor phenytoin therapy due to inconsistent effects of thioridazine on phenytoin levels. Potentially Fatal: Increased risk of QT prolongation with class IA and class II antiarrhythmics, astemizole, cisapride, pimozide, droperidol, erythromycin IV, sparfloxacin, terfenadine, clarithromycin and other drugs that may prolong QT interval. Potentiates CNS depression with opioids. Increased risk of arrhythmias with ephedrine-like drugs e.g. phenylpropanolamine. Increased thioridazone levels with fluovoxamine, pindolol, propranolol, ritonavir and other CYP2D6 isoenzymes inhibitors (e.g. fluoxetine, paroxetine).

Food interactions

[UNSAFE] It is unsafe to consume alcohol with Thioridazine hydrochloride.

Use in pregnancy

[CONSULT YOUR DOCTOR] Thioridazine hydrochloride may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Use in lactation

[CONSULT YOUR DOCTOR] Thioridazine hydrochloride is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Renal / hepatic impairment

[CONSULT YOUR DOCTOR] There is limited information available on the use of Thioridazine hydrochloride in patients with kidney disease. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Thioridazine hydrochloride in patients with liver disease. Please consult your doctor.

Common questions

How to treat erectile dysfunction with schizophrenia https://www.1mg.com/otc/himalaya-confido-tablet-otc90667One ?one tablet morning & evening after taking food , use at least 1-2 months Many times feel itching under my penis Is there any way reduce the itching take tablet levocet 5mg od for 5 days. keep it clean How long I have to use shicalm plus 5mg and amistride 50 mg for shizophrenia. I can have clear thoughts without medicine I tried.Even I am trying to stop nicotine. I want to cure completely and without medicine i want to stay again with a healthy brain. Schizophrenia is a chronic problem caused by Neuro chemical disturbance in brain. It is characterised by fear, odd experiences and distorted thought pattern. Treatment is with antipsychotic medicines which may need to continue throughout life. Coping with a mental disorder as serious as schizophrenia can be challenging, both for the person with the condition and for friends and family. Here are some ways to cope: 1. Learn about schizophrenia. Education about the disorder can help motivate the person with the disease to stick to the treatment plan. Education can help friends and family understand the disorder and be more compassionate with the person who has it. 2. Join a support group. Support groups for people with schizophrenia can help them reach out to others facing similar challenges. Support groups may also help family and friends cope. 3. Stay focused on goals. Managing schizophrenia is an ongoing process. Keeping treatment goals in mind can help the person with schizophrenia stay motivated. Help your loved one remember to take responsibility for managing the illness and working toward goals. 4. Ask about social services assistance. These services may be able to assist with affordable counselling services, job placements and other daily activities. 5. Learn relaxation and stress management. The person with schizophrenia and loved ones may benefit from stress-reduction techniques such as meditation, yoga or tai chi. Please see a psychiatrist for further guidance. I.am having red marks on.my panis glands nd these r having so.much eatching apply zole f ointment on it and take tablet levocetrizine 5mg once daily mother is patient of schizophrenia since last 6 years we were using senorm la 5mg ,by sun pharma , but now that injection is not available in market,kindly suggest the substitue There are other depot preparations available in market but they can be prescribed after proper clinical examination. Please see your psychiatrist. Hello Sir, i am getting red dots on the head of my penis and around foreskin and its very itchy espectially when i pull my foreskin back its leaves bad odour around my penis, and my penis itches so bad please sir help me. apply zole f cream over it. and take tablet levocet 5mg od for 3 days I am having irritation in my penis with redness and itchy feeling take tablet levocet 5mg od for 5days and apply zole f cream on it twice daily I had rashes on understomack.its itching and little pain I had rashes on under stomach its itching and little pain apply zole f cream over it twice daily and take tablet levocet 5mg od for 5days

⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.
Thioridazine hydrochloride — দাম, ব্যবহার, ডোজ ও পার্শ্বপ্রতিক্রিয়া | oshudhkosh